By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | FLEX | TE | D/ST |
| RB | Team | Opponent | |
| 1 | Melvin Gordon | SD | at OAK |
| 2 | Le’Veon Bell | PIT | NYJ |
| 3 | David Johnson | ARI | at SF |
| 4 | C.J. Anderson | DEN | ATL |
| 5 | LeSean McCoy | BUF | at LA |
| 6 | DeMarco Murray | TEN | at MIA |
| 7 | Todd Gurley | LA | BUF |
| 8 | Matt Forte | NYJ | at PIT |
| 9 | Frank Gore | IND | CHI |
| 10 | Jordan Howard | CHI | at IND |
| 11 | Ezekiel Elliott | DAL | CIN |
| 12 | Terrance West | BAL | WSH |
| 13 | LeGarrette Blount | NE | at CLE |
| 14 | Lamar Miller | HOU | at MIN |
| 15 | Latavius Murray | OAK | SD |
| 16 | Carlos Hyde | SF | ARI |
| 17 | Theo Riddick | DET | PHI |
| 18 | Eddie Lacy | GB | NYG |
| 19 | Devonta Freeman | ATL | at DEN |
| 20 | Isaiah Crowell | CLE | NE |
| 21 | Darren Sproles | PHI | at DET |
| 22 | Matt Jones | WSH | at BAL |
| 23 | Jeremy Hill | CIN | at DAL |
| 24 | James White | NE | at CLE |
| 25 | Jerick McKinnon | MIN | HOU |
| 26 | Fozzy Whittaker | CAR | TB |
| 27 | Ryan Mathews | PHI | at DET |
| 28 | Giovani Bernard | CIN | at DAL |
| 29 | Charles Sims | TB | at CAR |
| 30 | Duke Johnson Jr. | CLE | NE |
| 31 | Rashad Jennings | NYG | at GB |
| 32 | Bilal Powell | NYJ | at PIT |
| 33 | Cameron Artis-Payne | CAR | TB |
| 34 | DeAndre Washington | OAK | SD |
| 35 | Jacquizz Rodgers | TB | at CAR |
| 36 | Bobby Rainey | NYG | at GB |
| 37 | Dwayne Washington | DET | PHI |
| 38 | Josh Ferguson | IND | CHI |
| 39 | Matt Asiata | MIN | HOU |
| 40 | Dexter McCluster | SD | at OAK |
| 41 | Chris Thompson | WSH | at BAL |
| 42 | Shaun Draughn | SF | ARI |
| 43 | DeAngelo Williams | PIT | NYJ |
| 44 | Kenyan Drake | MIA | TEN |
| 45 | Devontae Booker | DEN | ATL |
| 46 | Jay Ajayi | MIA | TEN |
| 47 | Derrick Henry | TEN | at MIA |
| 48 | Orleans Darkwa | NYG | at GB |
| 49 | James Starks | GB | NYG |
| 50 | Mike Gillislee | BUF | at LA |
** Bye Weeks – Chiefs, Saints, Seahawks & Jaguars **