By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Ezekiel Elliott | DAL | @ IND |
| 2 | Todd Gurley II | LAR | PHI |
| 3 | Saquon Barkley | NYG | TEN |
| 4 | Christian McCaffrey | CAR | NO |
| 5 | Dalvin Cook | MIN | MIA |
| 6 | Melvin Gordon* | LAC | @ KC |
| 7 | Nick Chubb | CLE | @ DEN |
| 8 | Spencer Ware | KC | LAC |
| 9 | Alvin Kamara | NO | @ CAR |
| 10 | Leonard Fournette | JAX | WAS |
| 11 | David Johnson | ARI | @ ATL |
| 12 | Joe Mixon | CIN | OAK |
| 13 | Jaylen Samuels | PIT | NE |
| 14 | Philip Lindsay | DEN | CLE |
| 15 | Tevin Coleman | ATL | ARI |
| 16 | Kerryon Johnson* | DET | @ BUF |
| 17 | Derrick Henry | TEN | @ NYG |
| 18 | Jeff Wilson Jr. | SF | SEA |
| 19 | Aaron Jones | GB | @ CHI |
| 20 | Tarik Cohen | CHI | GB |
| 21 | Kenyan Drake | MIA | @ MIN |
| 22 | Doug Martin | OAK | @ CIN |
| 23 | Justin Jackson | LAC | @ KC |
| 24 | Lamar Miller | HOU | @ NYJ |
| 25 | Chris Carson | SEA | @ SF |
| 26 | Sony Michel | NE | @ PIT |
| 27 | Dion Lewis | TEN | @ NYG |
| 28 | James White | NE | @ PIT |
| 29 | Kenneth Dixon | BAL | TB |
| 30 | Mark Ingram II | NO | @ CAR |
| 31 | Elijah McGuire | NYJ | HOU |
| 32 | LeSean McCoy* | BUF | DET |
| 33 | Marlon Mack | IND | DAL |
| 34 | Kenneth Dixon | BAL | TB |
| 35 | Jalen Richard | OAK | @ CIN |
| 36 | Gus Edwards | BAL | TB |
| 37 | Jordan Howard | CHI | GB |
| 38 | Nyheim Hines | IND | DAL |
| 39 | Frank Gore | MIA | @ MIN |
| 40 | Adrian Peterson | WAS | @ JAX |
| 41 | Josh Adams | PHI | @ LAR |
| 42 | Chris Thompson | WAS | @ JAX |
| 43 | Peyton Barber | TB | @ BAL |
| 44 | Ito Smith | ATL | ARI |
| 45 | Theo Riddick | DET | @ BUF |
| 46 | Royce Freeman | DEN | CLE |
| 47 | Ty Montgomery | BAL | TB |
| 48 | Stevan Ridley | PIT | NE |
| 49 | T.J. Yeldon | JAX | WAS |
| 50 | Damien Williams | KC | LAC |
| 51 | Darren Sproles | PHI | @ LAR |
| 52 | Giovani Bernard | CIN | OAK |
| 53 | Chris Ivory | BUF | DET |
| 54 | Duke Johnson Jr. | CLE | @ DEN |
| 55 | Rashaad Penny | SEA | @ SF |