By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Christian McCaffrey | CAR | @ CLE |
| 2 | Ezekiel Elliott | DAL | PHI |
| 3 | Alvin Kamara | NO | @ TB |
| 4 | Todd Gurley II | LAR | @ CHI |
| 5 | Saquon Barkley | NYG | @ WAS |
| 6 | Philip Lindsay | DEN | @ SF |
| 7 | Aaron Jones | GB | ATL |
| 8 | Nick Chubb | CLE | CAR |
| 9 | Sony Michel | NE | @ MIA |
| 10 | Austin Ekeler | LAC | CIN |
| 11 | Joe Mixon | CIN | @ LAC |
| 12 | Leonard Fournette | JAX | @ TEN |
| 13 | David Johnson | ARI | DET |
| 14 | Kerryon Johnson* | DET | @ ARI |
| 15 | Lamar Miller | HOU | IND |
| 16 | Adrian Peterson | WAS | NYG |
| 17 | James White | NE | @ MIA |
| 18 | Kenyan Drake | MIA | NE |
| 19 | Tarik Cohen | CHI | LAR |
| 20 | Justin Jackson | LAC | CIN |
| 21 | Jeff Wilson Jr. | SF | DEN |
| 22 | LeSean McCoy | BUF | NYJ |
| 23 | Dalvin Cook | MIN | @ SEA |
| 24 | Gus Edwards | BAL | @ KC |
| 25 | Tevin Coleman | ATL | @ GB |
| 26 | Mark Ingram II | NO | @ TB |
| 27 | Jaylen Samuels | PIT | @ OAK |
| 28 | Spencer Ware | KC | BAL |
| 29 | Jalen Richard | OAK | PIT |
| 30 | Isaiah Crowell | NYJ | @ BUF |
| 31 | Chris Carson | SEA | MIN |
| 32 | Theo Riddick | DET | @ ARI |
| 33 | Dion Lewis | TEN | JAX |
| 34 | Marlon Mack | IND | @ HOU |
| 35 | Josh Adams | PHI | @ DAL |
| 36 | Peyton Barber | TB | NO |
| 37 | Frank Gore | MIA | NE |
| 38 | Ty Montgomery | BAL | @ KC |
| 39 | Doug Martin | OAK | PIT |
| 40 | Nyheim Hines | IND | @ HOU |
| 41 | Duke Johnson Jr. | CLE | CAR |
| 42 | Giovani Bernard | CIN | @ LAC |
| 43 | Chris Thompson | WAS | NYG |
| 44 | Derrick Henry | TEN | JAX |
| 45 | Damien Williams | KC | BAL |
| 46 | Stevan Ridley | PIT | @ OAK |
| 47 | Elijah McGuire | NYJ | @ BUF |
| 48 | Chase Edmonds | ARI | DET |
| 49 | LeGarrette Blount | DET | @ ARI |
| 50 | Mike Davis | SEA | MIN |
| 51 | Rashaad Penny | SEA | MIN |
| 52 | Rex Burkhead | NE | @ MIA |
| 53 | Corey Clement | PHI | @ DAL |
| 54 | Royce Freeman | DEN | @ SF |
| 55 | Kenneth Dixon | BAL | @ KC |
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