By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | FLEX | TE | D/ST |
| Player | Team | Opponent | |
| 1 | Le’Veon Bell | PIT | @IND |
| 2 | Leonard Fournette | JAX | LAC |
| 3 | Ezekiel Elliott | DAL | @ATL |
| 4 | Melvin Gordon | LAC | @JAX |
| 5 | LeSean McCoy | BUF | NO |
| 6 | Todd Gurley | LAR | HOU |
| 7 | Lamar Miller | HOU | @LAR |
| 8 | Mark Ingram | NO | @BUF |
| 9 | Jordan Howard | CHI | @GB |
| 10 | Alvin Kamara | NO | @BUF |
| 11 | Devonta Freeman | ATL | DAL |
| 12 | Carlos Hyde | SF | NYG |
| 13 | Christian McCaffrey | CAR | MIA |
| 14 | Matt Forte | NYJ | @TB |
| 15 | Jerrick McKinnon | MIN | @WSH |
| 16 | Frank Gore | IND | PIT |
| 17 | Adrian Peterson | ARI | SEA |
| 18 | Aaron Jones | GB | CHI |
| 19 | Chris Thompson | WSH | MIN |
| 20 | Duke Johnson Jr. | CLE | @DET |
| 21 | Joe Mixon | CIN | @TEN |
| 22 | DeMarco Murray | TEN | CIN |
| 23 | Orleans Darkwa | NYG | @SF |
| 24 | Isaiah Crowell | CLE | @DET |
| 25 | Bilal Powell | NYJ | @TB |
| 26 | Doug Martin | TB | NYJ |
| 27 | Ameer Abdullah | DET | CLE |
| 28 | James White | NE | @DEN |
| 29 | Tevin Coleman | ATL | DAL |
| 30 | Tarik Cohen | CHI | GB |
| 31 | Latavius Murray | MIN | @WSH |
| 32 | Theo Reddick | DET | CLE |
| 33 | Marlon Mack | IND | PIT |
| 34 | Ty Montgomery | GB | @CHI |
| 35 | Devontae Booker | DEN | NE |
| 36 | Derrick Henry | TEN | CIN |
| 37 | C.J. Anderson | DEN | NE |
| 38 | Rex Burkhead | NE | @DEN |
| 39 | Jonathan Stewart | CAR | MIA |
| 40 | Damien Williams | MIA | @CAR |
| 41 | Kenyan Drake | MIA | @CAR |
| 42 | Giovani Bernard | CIN | @TEN |
| 43 | Dion Lewis | NE | @DEN |
| 44 | Andre Ellington | ARI | SEA |
| 45 | Matt Breida | SF | NYG |
| 46 | Wayne Gallmam | NYG | @SF |
| 47 | Thomas Rawls | SEA | @ARI |
| 48 | Jamaal Charles | DEN | NE |
| 49 | Elijah McGuire | NYJ | @TB |
| 50 | Austin Ekeler | LAC | @JAX |
** Week 10 byes: Chiefs, Eagles, Raiders, & Ravens