By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | FLEX | TE | D/ST |
| RB | Team | Opponent | |
| 1 | DeMarco Murray | TEN | CLE |
| 2 | Le’Veon Bell | PIT | at MIA |
| 3 | LeSean McCoy | BUF | SF |
| 4 | Christine Michael | SEA | ATL |
| 5 | David Johnson | ARI | NYJ |
| 6 | Melvin Gordon | SD | DEN |
| 7 | C.J. Anderson | DEN | at SD |
| 8 | Lamar Miller | HOU | IND |
| 9 | Todd Gurley | LA | at DET |
| 10 | Mark Ingram | NO | CAR |
| 11 | Ezekiel Elliott | DAL | at GB |
| 12 | Carlos Hyde | SF | at BUF |
| 13 | Theo Riddick | DET | LA |
| 14 | Jordan Howard | CHI | JAX |
| 15 | Ryan Mathews | PHI | at WSH |
| 16 | Devonta Freeman | ATL | at SEA |
| 17 | Isaiah Crowell | CLE | at TEN |
| 18 | Jonathan Stewart | CAR | at NO |
| 19 | James White | NE | CIN |
| 20 | Matt Forte | NYJ | at ARI |
| 21 | Frank Gore | IND | at HOU |
| 22 | Eddie Lacy | GB | DAL |
| 23 | Tevin Coleman | ATL | at SEA |
| 24 | LeGarrette Blount | NE | CIN |
| 25 | Giovani Bernard | CIN | at NE |
| 26 | Terrance West | BAL | at NYG |
| 27 | Matt Jones | WSH | PHI |
| 28 | Spencer Ware | KC | at OAK |
| 29 | T.J. Yeldon | JAX | at CHI |
| 30 | Rashad Jennings | NYG | BAL |
| 31 | Arian Foster | MIA | PIT |
| 32 | Jamaal Charles | KC | at OAK |
| 33 | Darren Sproles | PHI | at WSH |
| 34 | Duke Johnson Jr. | CLE | at TEN |
| 35 | Bilal Powell | NYJ | at ARI |
| 36 | Bobby Rainey | NYG | BAL |
| 37 | DeAndre Washington | OAK | KC |
| 38 | Fozzy Whittaker | CAR | at NO |
| 39 | Jalen Richard | OAK | KC |
| 40 | Jeremy Hill | CIN | at NE |
| 41 | Jay Ajayi | MIA | PIT |
| 42 | Derrick Henry | TEN | CLE |
| 43 | Josh Ferguson | IND | at HOU |
| 44 | Chris Thompson | WSH | PHI |
| 45 | Devontae Booker | DEN | at SD |
| 46 | Chris Ivory | NYJ | at CHI |
| 47 | Shaun Draughn | SF | at BUF |
| 48 | Kenneth Dixon | BAL | at NYG |
| 49 | Mike Gillislee | BUF | SF |
| 50 | DeAngelo Williams | PIT | at MIA |
** Bye Weeks: Vikings & Buccaneers **