Fantasy Football Week 10 Start/Sit: Matchups to Target and Avoid

Club Fantasy’s Weekly Fantasy Football Matchup Report is here to help you set winning lineups. Unlike season-long fantasy points allowed rankings, our report focuses on the last four weeks, giving you a better look at how defenses are performing right now. Each week, we highlight the ten defenses allowing the most points to QBs, RBs, WRs, and TEs, along with the five toughest matchups. Use this recent data to guide your start/sit decisions or build a DFS lineup that can win the slate. Here are the matchups to target and avoid for NFL Week 10.

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Fantasy Football Week 10 Start/Sit Advice

Scoring Note: These rankings use the full PPR scoring format. However, there is not a big difference between the rankings in .5 or non-PPR scoring.

Quarterback Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target):

1. NYJ: plays vs BUF, consider Josh Allen.
2. TEN: plays vs JAX, consider Trevor Lawrence.
3. NE: plays @ DET, consider Jared Goff.
4. HOU: plays @ CLE, consider Deshaun Watson or Shedeur Sanders.
5. LV: plays vs SEA, consider Drew Lock or Jalen Milroe.
6. BAL: plays vs LAC, consider Justin Herbert.
7. ARI: plays vs LAR, consider Matthew Stafford.
8. NO: plays vs CAR, consider Bryce Young.
9. DEN: BYE.
10. NYG: plays vs WAS, consider Jayden Daniels.

Fewest Points Allowed Last 4 Weeks (Matchups to Fade):

1. BUF: plays @ NYJ, fade Geno Smith.
2. SEA: plays @ LV, fade Fernando Mendoza.
3. MIN: plays @ GB, fade Jordan Love.
4. TB: BYE.
5. JAX: plays @ TEN, fade Cam Ward.

Running Back Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target):

1. ATL: plays vs KC, consider Kenneth Walker and Emmett Johnson.
2. HOU: plays @ CLE, consider Quinshon Judkins and Dylan Sampson.
3. LV: plays vs SEA, consider Zach Charbonnet and Jadarian Price.
4. WAS: plays @ NYG, consider Cam Skattebo and Devin Singletary.
5. DAL: plays vs SF, consider Christian McCaffrey and Kaelon Black.
6. CAR: plays @ NO, consider Travis Etienne, Alvin Kamara, and Audric Estime.
7. TEN: plays vs JAX, consider Bhayshul Tuten and Chris Rodriguez.
8. MIN: plays @ GB, consider Kaleb Johnson and Pierre Strong.
9. CLE: plays vs HOU, consider Woody Marks and David Montgomery.
10. NYJ: plays vs BUF, consider James Cook.

Fewest Points Allowed Last 4 Weeks (Matchups to Fade):

1. TB: BYE.
2. NE: plays @ DET, fade Jahmyr Gibbs.
3. SF: plays @ DAL, fade Javonte Williams and Kendre Miller.
4. DET: plays vs NE, fade Rhamondre Stevenson and Corey Kiner.
5. PIT: plays @ CIN, fade Chase Brown and Samaje Perine.

Wide Receiver Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target):

1. TEN: plays vs JAX, consider Parker Washington and Jakobi Meyers.
2. NE: plays @ DET, consider Amon-Ra St. Brown and Jameson Williams.
3. LAC: plays @ BAL, consider Zay Flowers.
4. GB: plays vs MIN, consider Justin Jefferson and Jordan Addison.
5. PHI: BYE.
6. LV: plays vs SEA, consider Jaxon Smith-Njigba and Rashid Shaheed.
7. CAR: plays @ NO, consider Chris Olave, Jordyn Tyson, and Devaughn Vele.
8. HOU: plays @ CLE, consider Denzel Boston and KC Concepcion.
9. NO: plays vs CAR, consider Tetairoa McMillan and Jalen Coker.
10. CIN: plays vs PIT, consider DK Metcalf and Germie Bernard.

Fewest Points Allowed Last 4 Weeks (Matchups to Fade):

1. BUF: plays @ NYJ, fade Garrett Wilson, Adonai Mitchell, and Omar Cooper.
2. SEA: plays @ LV, fade Tre Tucker.
3. MIN: plays @ GB, fade Christian Watson and Matthew Golden.
4. CLE: plays vs HOU, fade Nico Collins, Marvin Harrison, Kayshon Boutte, Tank Dell,  and Xavier Hutchinson.
5. DET: plays vs NE, fade A.J. Brown and DeMario Douglas.

Tight End Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target):

1. DEN: BYE.
2. SF: plays @ DAL, consider Brevyn Spann-Ford.
3. NYJ: plays vs BUF, consider Dalton Kincaid.
4. TEN: plays vs JAX, consider Brenton Strange.
5. LAR: plays @ ARI, consider Trey McBride.
6. BAL: plays vs LAC, consider Oronde Gadsden.
7. CHI: BYE.
8. NO: plays vs CAR, consider Darren Waller and Tommy Tremble.
9. LV: plays vs SEA, consider AJ Barner.
10. CLE: plays vs HOU, consider Dalton Schultz.

Fewest Points Allowed Last 4 Weeks (Matchups to Fade):

1. NYG: plays vs WAS, fade Chig Okonkwo.
2. LAC: plays @ BAL, fade Mark Andrews.
3. GB: plays vs MIN, fade T.J. Hockenson.
4. CAR: plays @ NO, fade Juwan Johnson.
5. ATL: plays vs KC, fade Travis Kelce.

Looking for more help with NFL Week 10?

Here are Club Fantasy’s Week 10 rankings! Also, you’ll find the rest of our fantasy football articles here!

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