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Fantasy Football Week 5 Start/Sit: Matchups to Target and Avoid

Fantasy Football 2026

Club Fantasy’s Weekly Fantasy Football Matchup Report is here to help you set winning lineups. Each week, we highlight the ten defenses allowing the most points to QBs, RBs, WRs, and TEs, along with the five toughest matchups. Use this data to guide your start/sit decisions or build a DFS lineup that can win the slate. Here are the matchups to target and avoid for NFL Week 5.

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Fantasy Football Week 5 Start/Sit Advice

Scoring Note: These rankings use the full PPR scoring format. However, there is not a big difference between the rankings in .5 or non-PPR scoring.

Quarterback Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target):

  1. DET: plays @ ARI, consider Jacoby Brissett.
  2. DAL: plays vs TB, consider Jalon Daniels.
  3. WAS: plays vs NYG, consider Jameis Winston.
  4. BUF: plays @ LAR, consider Matthew Stafford.
  5. IND: plays @ PIT, consider Aaron Rodgers.
  6. ARI: plays vs DET, consider Jared Goff.
  7. HOU: plays @ TEN, consider Cam Ward.
  8. CAR: BYE.
  9. PHI: plays @ JAX, consider Trevor Lawrence.
  10. CLE: plays @ NYJ, consider Geno Smith

Fewest Points Allowed Last 4 Weeks (Matchups to Fade):

  1. MIN: plays @ NO, fade Tyler Shough.
  2. SEA: plays vs SF, fade Brock Purdy.
  3. KC: BYE.
  4. PIT: plays vs IND, fade Daniel Jones.
  5. NYJ: plays vs CLE, fade Deshaun Watson.

Running Back Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target):

  1. NO: plays vs MIN, consider Aaron Jones.
  2. MIA: plays vs CIN, consider Chase Brown.
  3. GB: plays vs CHI, consider D’Andre Swift and Kyle Monangai.
  4. NYJ: plays vs CLE, consider Quinshon Judkins.
  5. CAR: BYE.
  6. BUF: plays @ LAR, consider Kyren Williams and Blake Corum.
  7. DEN: plays @ LAC, consider Omarion Hampton and Keaton Mitchell.
  8. PIT: plays vs IND, consider Jonathan Taylor.
  9. SF: plays @ SEA, consider Emanuel Wilson.
  10. IND: plays @ PIT, consider Jaylen Warren and Rico Dowdle.

Fewest Points Allowed Last 3 Weeks (Matchups to Fade):

  1. MIN: plays @ NO, fade Alvin Kamara.
  2. LAR: plays vs BUF, fade James Cook.
  3. ARI: plays vs DET, fade Jahmyr Gibbs.
  4. WAS: plays vs NYG, fade Cam Skattebo.
  5. CLE: plays @ NYJ, fade Breece Hall and Braelon Allen.

Wide Receiver Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target):

  1. HOU: plays @ TEN, consider Carnell Tate and Wan’Dale Robinson.
  2. DET: plays @ ARI, consider Michael Wilson and Marvin Harrison Jr.
  3. BUF: plays @ LAR, consider Puka Nacua and Davante Adams.
  4. WAS: plays vs NYG, consider Malik Nabers and Malachi Fields.
  5. ARI: plays vs DET, consider Amon-Ra St. Brown and Jameson Williams.
  6. ATL: plays vs BAL, consider Zay Flowers.
  7. BAL: plays @ ATL, consider Drake London.
  8. CLE: plays @ NYJ, consider Garrett Wilson.
  9. JAX: plays vs PHI, consider Devonta Smith and Dontayvion Wicks.
  10. PHI: plays @ JAX, consider Parker Washington, Jakobi Meyers, and Brian Thomas Jr.

Fewest Points Allowed Last 4 Weeks (Matchups to Fade):

  1. KC: BYE.
  2. SEA: plays vs SF, fade Mike Evans and Deebo Samuel.
  3. MIA: plays vs CIN, fade Ja’Marr Chase, Tee Higgins, and Dohnte Myers.
  4. TB: plays @ DAL, fade CeeDee Lamb and George Pickens.
  5. CHI: plays @ GB, fade Christian Watson and Matthew Golden.

Tight End Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target):

  1. DET: plays @ ARI, consider Trey McBride.
  2. KC: BYE.
  3. ARI: plays vs DET, consider Sam LaPorta.
  4. MIA: plays vs CIN, consider Mike Gesicki.
  5. WAS: plays vs NYG, consider Isaiah Likely.
  6. LV: plays @ NE, consider Hunter Henry.
  7. CIN: plays @ MIA, consider Greg Dulcich.
  8. TB: plays @ DAL, consider Jake Ferguson.
  9. NO: plays vs MIN, consider T.J. Hockenson.
  10. CLE: plays @ NYJ, consider Kenyon Sadiq.

Fewest Points Allowed Last 3 Weeks (Matchups to Fade):

  1. NE: plays vs LV, fade Brock Bowers.
  2. LAR: plays vs BUF, fade Dalton Kincaid.
  3. CHI: plays @ GB, fade Tucker Kraft.
  4. MIN: plays @ NO, fade Juwan Johnson.
  5. PHI: plays @ JAX, fade Brenton Strange.

Looking for more help with NFL Week 5?

Here are Club Fantasy’s Week 5 rankings! Also, you’ll find the rest of our fantasy football articles here!

Finally, don’t forget to tune in to our YouTube channel every Wednesday at 9 pm EST for No Punt Intended. Josh, Joe, and Ryan will help get you ready for your Week 5 fantasy matchups!


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