Fantasy Football Week 16 Start/Sit: Matchups to Target and Avoid

Welcome to Club Fantasy’s Weekly Start/Sit Matchup Report, a data-driven guide to setting winning lineups. Each week, we highlight the defenses allowing the most and fewest fantasy points to quarterbacks, running backs, wide receivers, and tight ends over the last four weeks.

This article doesn’t just provide season-long data you’ll find on most sites; it’s recent, actionable info to help you spot hot and cold matchups before your competition does. Use it to guide your start/sit decisions or build a DFS lineup that can win the slate.

Here are the fantasy matchups to target and avoid for NFL Week 16.

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Fantasy Football Week 16 Start Sit Advice

Scoring Note: These rankings use the full PPR scoring format. However, there is not a big difference between the rankings in .5 or non-PPR scoring.

Quarterback Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

1. DAL: plays LAC, consider Justin Herbert
2. TEN: plays KC, consider Gardner Minshew
3. DET: plays PIT, consider Aaron Rodgers
4. TB: plays @ CAR, consider Bryce Young
5. ARI: plays ATL, consider Kirk Cousins
6. WAS: plays PHI, consider Jalen Hurts
7. PIT: plays @ DET, consider Jared Goff
8. CIN: plays @ MIA, consider Tua Tagovailoa
9. LAR: plays @ SEA, consider Sam Darnold
10. NYJ: plays @ NO, consider Tyler Shough

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

1. MIN: plays @ NYG, fade Jaxson Dart
2. SEA: plays LAR, fade Matthew Stafford
3. LAC: plays @ DAL, fade Dak Prescott
4. JAX: plays @ DEN, fade Bo Nix
5. SF: plays @ IND, fade Philip Rivers

Running Back Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

1. NYJ: plays @ NO, consider Devin Neal or Audric Estime
2. NYG: plays MIN, consider Aaron Jones and Jordan Mason
3. ARI: plays ATL, consider Bijan Robinson and Tyler Allgeier
4. LV: plays @ HOU, consider Woody Marks, Nick Chubb, or Jawhar Jordan
5. CLE: plays BUF, consider James Cook
6. WAS: plays PHI, consider Saquon Barkley
7. CAR: plays TB, consider Bucky Irving
8. NE: plays @ BAL, consider Derrick Henry
9. DAL: plays LAC, consider Omarion Hampton and Kimani Vidal
10. BAL: plays NE, consider TreVeyon Henderson and Rhamondre Stevenson

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

1. LAC: plays @ DAL, fade Javonte Williams and Malik Davis
2. MIA: plays CIN, fade Chase Brown and Samaje Perine
3. ATL: plays @ ARI, fade Michael Carter and Emari Demercado
4. CHI: plays GB, fade Josh Jacobs
5. GB: plays @ CHI, fade D’Andre Swift and Kyle Monangai

Wide Receiver Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

1. DET: plays PIT, consider D.K. Metcalf and Calvin Austin
2. LAR: plays @ SEA, consider Jaxon Smith-Njigba and Rashid Shaheed
3. DAL: plays LAC, consider Ladd McConkey and Keenan Allen
4. ATL: plays @ ARI, consider Marvin Harrison Jr. and Michael Wilson
5. IND: plays SF, consider Jauan Jennings
6. GB: plays @ CHI, consider D.J. Moore, Rome Odunze, and Luther Burden
7. TEN: plays KC, consider Rashee Rice
8. CAR: plays TB, consider Mike Evans, Chris Godwin, and Emeka Egbuka
9. DEN: plays JAX, consider Jakobi Meyers and Brian Thomas
10. NYG: plays MIN, consider Justin Jefferson and Jordan Addison

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

1. SEA: plays LAR, fade Puka Nacua and Davante Adams
2. CIN: plays @ MIA, fade Jaylen Waddle
3. SF: plays @ IND, fade Michael Pittman Jr. and Alec Pierce
4. PHI: plays @ WAS, fade Terry McLaurin and Deebo Samuel
5. LAC: plays @ DAL, fade CeeDee Lamb and George Pickens

Tight End Matchups

Are you looking for more help with NFL Week 16?

Here are Club Fantasy’s Week 16 rankings! Also, you’ll find the rest of our fantasy football articles here!

Finally, don’t forget to tune into our YouTube channel every Wednesday at 8 pm EST for No Punt Intended. Josh, Joe, and Ryan will help get you ready for your Week 16 fantasy matchups!