Fantasy Football Week 10 Start/Sit: Matchups to Target and Avoid

Welcome to Club Fantasy’s Weekly Start/Sit Matchup Report, a data-driven guide to setting winning lineups. Each week, we highlight the defenses allowing the most and fewest fantasy points to quarterbacks, running backs, wide receivers, and tight ends over the last four weeks.

This isn’t just season-long data you’ll find on most sites; it’s recent, actionable info to help you spot hot and cold matchups before your competition does. Use it to guide your start/sit decisions or build a DFS lineup that can win the slate.

Here are the fantasy matchups to target and avoid for NFL Week 10.

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Fantasy Football Week 10 Start Sit Advice

Scoring Note: These rankings use the full PPR scoring format. However, there is not a big difference between the rankings in .5 or non-PPR scoring.

Quarterback Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

1. NYG: plays @ CHI, consider Caleb Williams
2. JAX: plays @ HOU, consider C.J. Stroud
3. WAS: plays vs DET, consider Jared Goff
4. CIN: BYE
5. MIN: plays vs BAL, consider Lamar Jackson
6. DAL: BYE
7. CHI: plays vs NYG, consider Jaxson Dart
8. TEN: BYE
9. SF: plays vs LAR, consider Matthew Stafford
10. DET: plays @ WAS, consider Marcus Mariota

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

1. BUF: plays @ MIA, fade Tua Tagovailoa
2. LAC: plays vs PIT, fade Aaron Rodgers
3. BAL: plays @ MIN, fade J.J. McCarthy
4. TB: plays vs NE, fade Drake Maye
5. LAR: plays @ SF, fade Brock Purdy or Mac Jones

Running Back Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

1. CIN: BYE
2. ATL: plays @ IND, consider Jonathan Taylor
3. NYG: plays @ CHI, consider D’Andre Swift and Kyle Monangai
4. TB: plays vs NE, consider Rhamondre Stevenson and TreVeyon Henderson
5. DAL: BYE
6. BUF: plays @ MIA, consider De’Von Achane
7. LAC: plays vs PIT, consider Jaylen Warren
8. MIA: plays vs BUF, consider James Cook
9. NYJ: plays vs CLE, consider Quinshon Judkins
10. LV: plays @ DEN, consider JK Dobbins and RJ Harvey

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

1. LAR: plays @ SF, fade Christian McCaffrey
2. DET: plays @ WAS, fade Jacory Croskey-Merritt
3. JAX: plays @ HOU, fade Nick Chubb and Woody Marks
4. KC: BYE
5. CHI: plays vs NYG, fade Tyrone Tracy and Devin Singletary

Wide Receiver Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

1. PIT: plays @ LAC, consider Ladd McConkey, Keenan Allen, and Quentin Johnston
2. MIN: plays BAL, consider Zay Flowers
3. CHI: plays NYG, consider Darius Slayton and Wan’Dale Robinson
4. WAS: plays DET, consider Amon-Ra St. Brown and Jameson Williams
5. SF: plays LAR, consider Puka Nacua and Davante Adams
6. LV: plays DEN, consider Courtland Sutton and Troy Franklin
7. DET: plays WAS, consider Deebo Samuel
8. TEN: BYE
9. NO: plays @ CAR, consider Tetairoa McMillan
10. DAL: BYE

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

1. MIA: plays BUF, fade Khalil Shakir
2. KC: BYE
3. LAC: plays PIT, fade DK Metcalf
4. HOU: plays JAX, fade Brian Thomas, Jakobi Meyers, and Parker Washington
5. DEN: plays LV, fade Tre Tucker and Tyler Lockett

Tight End Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

1. JAX: plays @ HOU, consider Dalton Schultz
2. CIN: BYE
3. IND: plays ATL, consider Kyle Pitts
4. PIT: plays @ LAC, consider Oronde Gadsden
5. MIA: plays BUF, consider Dalton Kincaid
6. WAS: plays DET, consider Sam LaPorta
7. ARI: plays @ SEA, consider AJ Barner or Eliajah Arroyo
8. CHI: plays NYG, consider Theo Johnson
9. NYG: plays @ CHI, consider Colston Loveland
10. MIN: plays BAL, consider Mark Andrews

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

1. ATL: plays @ IND, fade Tyler Warren
2. BUF: plays @ MIA, fade whoever they decide to start
3. PHI: plays @ GB, fade Luke Musgrave
4. LAR: plays @ SF, fade George Kittle
5. SF: plays LAR, fade Tyler Higbee

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Are you looking for more help with NFL Week 10?

Here are Club Fantasy’s Week 10 rankings! Also, you’ll find the rest of our fantasy football articles here!

Finally, don’t forget to tune into our YouTube channel every Wednesday at 8 pm EST for No Punt Intended. Josh, Joe, and Ryan will help get you ready for your Week 10 fantasy matchups!