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Fantasy Football Matchup Report: Starts and Sits for Week 2

Fantasy Football 2025

Club Fantasy’s Weekly Fantasy Football Matchup Report is here to help you set winning lineups. Each week, we highlight the ten defenses allowing the most points to QBs, RBs, WRs, and TEs, along with the five toughest matchups. Use this data to guide your start/sit decisions or build a DFS lineup that can win the slate. Here are the matchups to target and avoid for NFL Week 2.

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Week 2 Fantasy Football Matchups

Scoring Note: These rankings use the full PPR scoring format. However, there is not a big difference between the rankings in .5 or non-PPR scoring.

Quarterback Matchups

Most Points Allowed Last Week (Matchups to Target):

  1. BAL: plays CLE, consider Joe Flacco
  2. PIT: plays SEA, consider Sam Darnold
  3. MIA: plays NE, consider Drake Maye
  4. BUF: plays @ NYJ, consider Justin Fields
  5. KC: plays PHI, consider Jalen Hurts
  6. LAC: plays @ LV, consider Geno Smith
  7. NYJ: plays BUF, consider Josh Allen
  8. DAL: plays NYG, consider Russell Wilson
  9. MIN: plays ATL, consider Michael Penix
  10. TB: plays @ HOU, consider C.J. Stroud

Fewest Points Allowed Last Week (Matchups to Fade):

  1. DEN: plays @ IND, fade Daniel Jones
  2. IND: plays DEN, fade Bo Nix
  3. SF: plays @ NO, fade Spencer Rattler
  4. PHI: plays @ KC, fade Patrick Mahomes
  5. LAR: plays @ TEN, fade Cam Ward

Running Back Matchups

Most Points Allowed Last Week (Matchups to Target):

  1. SEA: plays @ PIT, consider Jaylen Warren and Kaleb Johnson
  2. BUF: plays @ NYJ, consider Breece Hall and Braelon Allen
  3. TEN: plays vs. LAR, consider Kyren Williams
  4. TB: plays @ HOU, consider Nick Chubb
  5. PHI: plays @ KC, consider Isiah Pacheco
  6. NYG: plays @ DAL, consider Javonte Williams
  7. PIT: plays vs. SEA, consider Kenneth Walker and Zach Charbonnet
  8. CIN: plays vs. JAX, consider Travis Etienne and Bhayshul Tuten
  9. BAL: plays vs. CLE, consider Dylan Sampson and Jerome Ford, maybe Quinshon Judkins
  10. CHI: plays @ DET, consider Jahmyr Gibbs and David Montgomery

Fewest Points Allowed Last Week (Matchups to Fade):

  1. WAS: plays @ GB, fade Josh Jacobs 
  2. LAC: plays @ LV, fade Ashton Jeanty
  3. KC: plays vs. PHI, fade Saquon Barkley
  4. DEN: plays @ IND, fade Jonathan Taylor
  5. LAR: plays @ TEN, fade Tony Pollard

Wide Receiver Matchups

Most Points Allowed Last Week (Matchups to Target):

  1. KC: plays vs. PHI, consider A.J. Brown and DeVonta Smith
  2. BAL: plays vs. CLE, consider Jerry Jeudy and Cedric Tillman
  3. BUF: plays @ NYJ, consider Garrett Wilson
  4. NE: plays @ MIA, consider Tyreek Hill and Jaylen Waddle
  5. ATL: plays @ MIN, consider Justin Jefferson
  6. LV: plays vs. LAC, consider Ladd McConkey, Quentin Johnston, and Keenan Allen
  7. HOU: plays vs. TB, consider Mike Evans and Emeka Egbuka
  8. NYJ: plays vs. BUF, consider Keon Coleman, Khalil Shakir, and Josh Palmer
  9. NYG: plays @ DAL, consider CeeDee Lamb and George Pickens
  10. LAC: plays @ LV, consider Jakobi Meyers, D’Onte Thornton, and Tre Tucker

Fewest Points Allowed Last Week (Matchups to Fade):

  1. CLE: plays @ BAL, fade Zay Flowers, Rashod Bateman, and DeAndre Hopkins
  2. DEN: plays @ IND, fade Michael Pittman and Josh Downs
  3. DAL: plays vs. NYG, fade Malik Nabers and Wan’Dale Robinson
  4. SEA: plays @ PIT, fade DK Metcalf and Calvin Austin
  5. CHI: plays @ DET, fade Amon-Ra St. Brown and Jameson Williams

Tight End Matchups

Most Points Allowed Last Week (Matchups to Target):

  1. SEA: plays @ PIT, consider Jonnu Smith and Pat Freiermuth
  2. NE: plays @ MIA, consider Darren Waller
  3. BAL: plays vs. CLE, consider David Njoku and Harold Fannin
  4. CIN: plays vs. JAX, consider Brenton Strange
  5. NYJ: plays vs. BUF, consider Dalton Kincaid
  6. MIA: plays vs. NE, consider Hunter Henry
  7. CAR: plays @ ARI, consider Trey McBride
  8. ARI: plays vs. CAR, consider Ja’Tavian Sanders
  9. NO: plays vs. SF, consider Jake Tonges and Luke Farrell
  10. CLE: plays @ BAL, consider Mark Andrews, maybe Isaiah Likely

Fewest Points Allowed Last Week (Matchups to Fade):

  1. ATL: plays @ MIN, fade T.J. Hockenson
  2. BUF: plays @ NYJ, fade Mason Taylor
  3. SF: plays @ NO, fade Juwan Johnson
  4. WAS: plays @ GB, fade Tucker Kraft
  5. IND: plays vs. DEN, fade Evan Engram

Are you looking for more help with NFL Week 2?

Here are Club Fantasy’s Week 2 rankings! Also, you’ll find the rest of our fantasy football articles here!

Finally, don’t forget to tune into our YouTube channel every Wednesday at 8 pm EST for No Punt Intended. Josh, Joe, and Ryan will help get you ready for your Week 2 fantasy matchups!


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