By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Christian McCaffrey | CAR | ATL |
| 2 | Ezekiel Elliott | DAL | TB |
| 3 | Nick Chubb | CLE | CIN |
| 4 | Todd Gurley* | LAR | @ ARI |
| 5 | Saquon Barkley | NYG | @ IND |
| 6 | Alvin Kamara | NO | @ PIT |
| 7 | David Johnson | ARI | LAR |
| 8 | Melvin Gordon* | LAC | BAL |
| 9 | Joe Mixon | CIN | @ CLE |
| 10 | Marlon Mack | IND | NYG |
| 11 | Lamar Miller* | HOU | @ PHI |
| 12 | Chris Carson | SEA | KC |
| 13 | James Conner* | PIT | @ NO |
| 14 | Dalvin Cook | MIN | @ DET |
| 15 | Philip Lindsay | DEN | @ OAK |
| 16 | Derrick Henry | TEN | WAS |
| 17 | Tarik Cohen | CHI | @ SF |
| 18 | Elijah McGuire | NYJ | GB |
| 19 | Leonard Fournette | JAX | @ MIA |
| 20 | Spencer Ware* | KC | @ SEA |
| 21 | James White | NE | BUF |
| 22 | Gus Edwards | BAL | @ LAC |
| 23 | Sony Michel | NE | BUF |
| 24 | Tevin Coleman | ATL | @ CAR |
| 25 | Jamaal Williams | GB | @ NYJ |
| 26 | Mark Ingram | NO | PIT |
| 27 | Peyton Barber | TB | @ DAL |
| 28 | Jalen Richard | OAK | DEN |
| 29 | Matt Breida | SF | CHI |
| 30 | Jordan Howard | CHI | @ SF |
| 31 | LeSean McCoy* | BUF | @ NE |
| 32 | Damien Williams | KC | @ SEA |
| 33 | Kenyan Drake | MIA | JAX |
| 34 | Jaylen Samuels | PIT | @ NO |
| 35 | Dion Lewis | TEN | WAS |
| 36 | Nyheim Hines | IND | NYG |
| 37 | Doug Martin | OAK | DEN |
| 38 | Theo Riddick | MIN | @ DET |
| 39 | Josh Adams | PHI | HOU |
| 40 | Adrian Peterson* | WAS | @ TEN |
| 41 | Latavius Murray | MIN | @ DET |
| 42 | Chris Thompson | WAS | @ TEN |
| 43 | Darren Sproles | PHI | HOU |
| 44 | Zach Zenner | DET | MIN |
| 45 | Kalen Ballage | MIA | JAX |
| 46 | Duke Johnson Jr. | CLE | CIN |
| 47 | Justin Jackson | LAC | BAL |
| 48 | Kenneth Dixon | BAL | @ LAC |
| 49 | Trenton Cannon | NYJ | GB |
| 50 | Brian Hill | ATL | @ CAR |
| 51 | Jeff Wilson Jr. | SF | CHI |
| 52 | Mike Davis | SEA | KC |
| 53 | Royce Freeman | DEN | @ OAK |
| 54 | Rex Burkhead | NE | BUF |
| 55 | Alfred Blue | HOU | @ PHI |
* denotes questionable as of Tuesday, December 18, 2018