By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Saquon Barkley | NYG | @ PHI |
| 2 | Melvin Gordon | LAC | ARI |
| 3 | Alvin Kamara | NO | ATL |
| 4 | James Conner | PIT | @ DEN |
| 5 | David Johnson | ARI | @ LAC |
| 6 | Nick Chubb | CLE | @ CIN |
| 7 | Ezekiel Elliott | DAL | WAS |
| 8 | Joe Mixon | CIN | CLE |
| 9 | Leonard Fournette | JAX | @ BUF |
| 10 | Christian McCaffrey | CAR | SEA |
| 11 | Mark Ingram | NO | ATL |
| 12 | James White | NE | @ NYJ |
| 13 | Marlon Mack | IND | MIA |
| 14 | Aaron Jones | GB | @ MIN |
| 15 | Sony Michel | NE | @ NYJ |
| 16 | Tarik Cohen | CHI | @ DET |
| 17 | Duke Johnson Jr. | CLE | @ CIN |
| 18 | Dalvin Cook | MIN | GB |
| 19 | Matt Breida | SF | @ TB |
| 20 | Jordan Howard | CHI | @ DET |
| 21 | Philip Lindsay | DEN | PIT |
| 22 | Tevin Coleman | ATL | @ NO |
| 23 | Lamar Miller | HOU | TEN |
| 24 | Adrian Peterson | WAS | @ DAL |
| 25 | Chris Carson | SEA | @ CAR |
| 26 | Theo Riddick | DET | CHI |
| 27 | Josh Adams | PHI | NYG |
| 28 | Dion Lewis | TEN | @ HOU |
| 29 | Kenyan Drake | MIA | @ IND |
| 30 | LeSean McCoy | BUF | JAX |
| 31 | Isaiah Crowell | NYJ | NE |
| 32 | Jalen Richard | OAK | @ BAL |
| 33 | Peyton Barber | TB | SF |
| 34 | Frank Gore | MIA | @ IND |
| 35 | Gus Edwards | BAL | OAK |
| 36 | Royce Freeman | DEN | PIT |
| 37 | Nyheim Hines | IND | MIA |
| 38 | Rashaad Penny | SEA | @ CAR |
| 39 | Alex Collins | BAL | @ OAK |
| 40 | Elijah McGuire | NYJ | NE |
| 41 | LeGarrette Blount | DET | CHI |
| 42 | Austin Ekeler | LAC | ARI |
| 43 | Byron Marshall | WAS | @ DAL |
| 44 | Derrick Henry | TEN | @ HOU |
| 45 | T.J. Yeldon | JAX | @ BUF |
| 46 | Alfred Blue | HOU | TEN |
| 47 | Ito Smith | ATL | @ NO |
| 48 | Corey Clement | PHI | NYG |
| 49 | Mike Davis | SEA | @ CAR |
| 50 | DeAndre Washington | OAK | @ BAL |
Bye Weeks: Chiefs & Rams