By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Drew Brees | NO | ATL |
| 2 | Andrew Luck | IND | MIA |
| 3 | Matt Ryan | ATL | @ NO |
| 4 | Jameis Winston | TB | SF |
| 5 | Mitchell Trubisky | CHI | @ DET |
| 6 | Cam Newton | CAR | SEA |
| 7 | Aaron Rodgers | GB | @ MIN |
| 8 | Ben Roethlisberger | PIT | @ DEN |
| 9 | Russell Wilson | SEA | @ CAR |
| 10 | Kirk Cousins | MIN | GB |
| 11 | Carson Wentz | PHI | NYG |
| 12 | Deshaun Watson | HOU | TEN |
| 13 | Philip Rivers | LAC | ARI |
| 14 | Tom Brady | NE | @ NYJ |
| 15 | Baker Mayfield | CLE | @ CIN |
| 16 | Eli Manning | NYG | @ PHI |
| 17 | Andy Dalton | CIN | CLE |
| 18 | Lamar Jackson | BAL | OAK |
| 19 | Dak Prescott | DAL | WAS |
| 20 | Matthew Stafford | DET | CHI |
| 21 | Nick Mullens | SF | @ TB |
| 22 | Case Keenum | DEN | PIT |
| 23 | Josh McCown | NYJ | NE |
| 24 | Blake Bortles | JAX | @ BUF |
| 25 | Colt McCoy | WAS | @ DAL |
| 26 | Derek Carr | OAK | @ BAL |
| 27 | Ryan Tannehill | MIA | @ IND |
| 28 | Marcus Mariota | TEN | @ HOU |
| 29 | Josh Rosen | ARI | @ LAC |
| 30 | Josh Allen | BUF | JAX |
| 31 | Taysom Hill | NO | ATL |
Bye Weeks: Chiefs & Rams