By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Todd Gurley !! | LAR | KC |
| 2 | Saquon Barkley | NYG | TB |
| 3 | Ezekiel Elliott | DAL | @ ATL |
| 4 | Melvin Gordon | LAC | DEN |
| 5 | Christian McCaffrey | CAR | @ DET |
| 6 | David Johnson | ARI | OAK |
| 7 | James Conner | PIT | @ JAX |
| 8 | Alvin Kamara | NO | PHI |
| 9 | Kareem Hunt | KC | @ LAR |
| 10 | Aaron Jones | GB | @ SEA |
| 11 | Kerryon Johnson | DET | CAR |
| 12 | Dion Lewis | TEN | @ IND |
| 13 | Philip Lindsay | DEN | @ LAC |
| 14 | Tarik Cohen | CHI | MIN |
| 15 | Mark Ingram !! | NO | PHI |
| 16 | Leonard Fournette | JAX | PIT |
| 17 | Chris Carson | SEA | GB |
| 18 | Dalvin Cook | MIN | @ CHI |
| 19 | Joe Mixon | CIN | @ BAL |
| 20 | Tevin Coleman | ATL | DAL |
| 21 | Adrian Peterson | WAS | HOU |
| 22 | Lamar Miller | HOU | @ WAS |
| 23 | Marlon Mack | IND | TEN |
| 24 | Doug Martin | OAK | @ ARI |
| 25 | Alex Collins | BAL | CIN |
| 26 | Jalen Richard | OAK | @ ARI |
| 27 | Theo Riddick | DET | CAR |
| 28 | Latavius Murray | MIN | @ CHI |
| 29 | Jordan Howard | CHI | MIN |
| 30 | Kapri Bibbs | WAS | HOU |
| 31 | Austin Ekeler | LAC | DEN |
| 32 | Ito Smith | ATL | DAL |
| 33 | Josh Adams | PHI | @ NO |
| 34 | T.J. Yeldon | JAX | PIT |
| 35 | Mike Davis | SEA | GB |
| 36 | Nyheim Hines | IND | TEN |
| 37 | Wendell Smallwood | PHI | @ NO |
| 38 | Rashaad Penny | SEA | GB |
| 39 | Derrick Henry | TEN | @ IND |
| 40 | Royce Freeman | DEN | @ LAC |
| 41 | Giovani Bernard | CIN | @ BAL |
| 42 | Javorius “Buck” Allen | BAL | CIN |
| 43 | Corey Clement | PHI | @ NO |
| 44 | Devontae Booker | DEN | @ LAC |
| 45 | Jordan Wilkins | IND | TEN |
| 46 | Spencer Ware | KC | @LAR |
| 47 | Ty Montgomery | BAL | CIN |
| 48 | Carlos Hyde | JAX | PIT |
| 49 | Jaylen Samuels | PIT | @ JAX |
| 50 | Malcolm Brown | LAR | KC |
Bye Weeks: Bills, Browns, Dolphins, 49ers, Jets, Patriots
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