By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Patrick Mahomes | KC | @ LAR |
| 2 | Drew Brees | NO | PHI |
| 3 | Jared Goff | LAR | KC |
| 4 | Matt Ryan | ATL | DAL |
| 5 | Andrew Luck | IND | TEN |
| 6 | Cam Newton | CAR | @ DET |
| 7 | Ryan Fitzpatrick | TB | @ NYG |
| 8 | Mitchell Trubisky | CHI | MIN |
| 9 | Carson Wentz | PHI | @ NO |
| 10 | Aaron Rodgers | GB | @ SEA |
| 11 | Russell Wilson | SEA | GB |
| 12 | Ben Roethlisberger | PIT | @ JAX |
| 13 | Deshaun Watson | HOU | @ WAS |
| 14 | Philip Rivers | LAC | DEN |
| 15 | Kirk Cousins | MIN | @ CHI |
| 16 | Dak Prescott | DAL | @ ATL |
| 17 | Matthew Stafford | DET | CAR |
| 18 | Eli Manning | NYG | TB |
| 19 | Blake Bortles | JAX | PIT |
| 20 | Lamar Jackson | BAL | CIN |
| 21 | Josh Rosen | ARI | OAK |
| 22 | Andy Dalton | CIN | @ BAL |
| 23 | Marcus Mariota | TEN | @ IND |
| 24 | Case Keenum | DEN | @ LAC |
| 25 | Alex Smith | WAS | HOU |
| 26 | Derek Carr | OAK | @ ARI |
| 27 | Taysom Hill | NO | PHI |
Bye Weeks: Bills, Browns, Dolphins, 49ers, Jets, Patriots