By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Kareem Hunt | KC | ARI |
| 2 | Todd Gurley II | LAR | SEA |
| 3 | James Conner | PIT | CAR |
| 4 | Melvin Gordon | LAC | @ OAK |
| 5 | Alvin Kamara | NO | @ CIN |
| 6 | Saquon Barkley | NYG | @ SF |
| 7 | David Johnson | ARI | @ KC |
| 8 | Christian McCaffrey | CAR | @ PIT |
| 9 | Ezekiel Elliott | DAL | @ PHI |
| 10 | James White | NE | @ TEN |
| 11 | Adrian Peterson | WAS | @ TB |
| 12 | Duke Johnson Jr. | CLE | ATL |
| 13 | Tevin Coleman | ATL | @ CLE |
| 14 | Nick Chubb | CLE | ATL |
| 15 | Joe Mixon | CIN | NO |
| 16 | Tarik Cohen | CHI | DET |
| 17 | Dion Lewis | TEN | NE |
| 18 | Jordan Howard | CHI | DET |
| 19 | Marlon Mack | IND | JAX |
| 20 | Matt Breida | SF | NYG |
| 21 | Aaron Jones | GB | MIA |
| 22 | Kerryon Johnson | DET | @ CHI |
| 23 | Mark Ingram II | NO | @ CIN |
| 24 | Kenyan Drake | MIA | @ GB |
| 25 | Leonard Fournette | JAX | @ IND |
| 26 | Chris Carson | SEA | @ LAR |
| 27 | Isaiah Crowell | NYJ | BUF |
| 28 | Ito Smith | ATL | @ CLE |
| 29 | Jalen Richard | OAK | LAC |
| 30 | LeSean McCoy | BUF | @ NYJ |
| 31 | Doug Martin | OAK | LAC |
| 32 | Chris Ivory | BUF | @ NYJ |
| 33 | Sony Michel | NE | @ TEN |
| 34 | Chris Thompson | WAS | @ TB |
| 35 | T.J. Yeldon | JAX | @ IND |
| 36 | Elijah McGuire | NYJ | BUF |
| 37 | Austin Ekeler | LAC | @ OAK |
| 38 | Theo Riddick | DET | @ CHI |
| 39 | Wendell Smallwood | PHI | DAL |
| 40 | Peyton Barber | TB | WAS |
| 41 | Frank Gore | MIA | @ GB |
| 42 | Mike Davis | SEA | @ LAR |
| 43 | Nyheim Hines | IND | JAX |
| 44 | Carlos Hyde | JAX | @ IND |
| 45 | Derrick Henry | TEN | NE |
| 46 | Jamaal Williams | GB | MIA |
| 47 | Alfred Morris | SF | NYG |
| 48 | Corey Clement | PHI | DAL |
| 49 | LeGarrette Blount | DET | @ CHI |
| 50 | Spencer Ware | KC | ARI |
Bye Weeks: Broncos, Ravens, Texans, Vikings