By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Todd Gurley II | LAR | GB |
| 2 | Kareem Hunt | KC | DEN |
| 3 | James Conner | PIT | CLE |
| 4 | Saquon Barkley | NYG | WAS |
| 5 | David Johnson | ARI | SF |
| 6 | Alvin Kamara | NO | @ MIN |
| 7 | Joe Mixon | CIN | TB |
| 8 | James White | NE | @ BUF |
| 9 | Marlon Mack | IND | @ OAK |
| 10 | Matt Breida | SF | @ ARI |
| 11 | Tarik Cohen | CHI | NYJ |
| 12 | Philip Lindsay | DEN | @ KC |
| 13 | Christian McCaffrey | CAR | BAL |
| 14 | Adrian Peterson | WAS | @ NYG |
| 15 | Lamar Miller | HOU | MIA |
| 16 | Mark Ingram | NO | @ MIN |
| 17 | Kenyan Drake | MIA | @ HOU |
| 18 | Chris Carson | SEA | @ DET |
| 19 | T.J. Yeldon | JAX | PHI |
| 20 | LeSean McCoy | BUF | NE |
| 21 | Doug Martin | OAK | IND |
| 22 | Nick Chubb | CLE | @ PIT |
| 23 | Kerryon Johnson | DET | SEA |
| 24 | Isaiah Crowell | NYJ | @ CHI |
| 25 | Kenjon Barner | NE | @ BUF |
| 26 | Latavius Murray | MIN | NO |
| 27 | Jalen Richard | OAK | IND |
| 28 | Alex Collins | BAL | @ CAR |
| 29 | Javorius “Buck” Allen | BAL | @ CAR |
| 30 | Peyton Barber | TB | @ CIN |
| 31 | Dalvin Cook | MIN | NO |
| 32 | Kapri Bibbs | WAS | @ NYG |
| 33 | Jordan Howard | CHI | NYJ |
| 34 | Nyheim Hines | IND | @ OAK |
| 35 | Bilal Powell | NYJ | @ CHI |
| 36 | Wendell Smallwood | PHI | @ JAX |
| 37 | Corey Clement | PHI | @ JAX |
| 38 | Duke Johnson Jr. | CLE | @ PIT |
| 39 | Ronald Jones II | TB | @ CIN |
| 40 | Raheem Mostart | SF | @ ARI |
| 41 | Aaron Jones | GB | @ LAR |
| 42 | Carlos Hyde | JAX | PHI |
| 43 | Chris Ivory | BUF | NE |
| 44 | Alfred Blue | HOU | MIA |
| 45 | Royce Freeman | DEN | @ KC |
| 46 | Devontae Booker | DEN | @ KC |
| 47 | Ty Montgomery | GB | @ LAR |
| 48 | Mike Davis | SEA | @ DET |
| 49 | LeGarrette Blount | DET | SEA |
| 50 | Frank Gore | MIA | @ HOU |
** Bye Weeks: Chargers, Cowboys, Falcons, and Titans