By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Andrew Luck | IND | @ OAK |
| 2 | Patrick Mahomes II | KC | DEN |
| 3 | Kirk Cousins | MIN | NO |
| 4 | Ben Roethlisberger | PIT | CLE |
| 5 | Aaron Rodgers | GB | @ LAR |
| 6 | Tom Brady | NE | @ BUF |
| 7 | Cam Newton | CAR | BAL |
| 8 | Mitchell Trubisky | CHI | NYJ |
| 9 | Andy Dalton | CIN | TB |
| 10 | Drew Brees | NO | @ MIN |
| 11 | Jared Goff | LAR | GB |
| 12 | Carson Wentz | PHI | @ JAX |
| 13 | Jameis Winston | TB | @ CIN |
| 14 | Matthew Stafford | DET | SEA |
| 15 | Baker Mayfield | CLE | @ PIT |
| 16 | Russell Wilson | SEA | @ DET |
| 17 | Deshaun Watson | HOU | MIA |
| 18 | Joe Flacco | BAL | @ CAR |
| 19 | Case Keenum | DEN | @ KC |
| 20 | Derek Carr | OAK | IND |
| 21 | C.J. Beathard | SF | @ ARI |
| 22 | Brock Osweiler | MIA | @ HOU |
| 23 | Eli Manning | NYG | WAS |
| 24 | Alex Smith | WAS | @ NYG |
| 25 | Blake Bortles | JAX | PHI |
| 26 | Josh Rosen | ARI | SF |
| 27 | Sam Darnold | NYJ | @ CHI |
| 28 | Derek Anderson | BUF | NE |
| 29 | Cody Kessler | JAX | PHI |
| 30 | Lamar Jackson | BAL | @ CAR |
** Bye Weeks: Chargers, Cowboys, Falcons, and Titans