By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Patrick Mahomes | KC | CIN |
| 2 | Matt Ryan | ATL | NYG |
| 3 | Jared Goff | LAR | @ SF |
| 4 | Andrew Luck | IND | BUF |
| 5 | Carson Wentz | PHI | CAR |
| 6 | Cam Newton | CAR | @ PHI |
| 7 | Kirk Cousins | MIN | @ NYJ |
| 8 | Philip Rivers | LAC | TEN |
| 9 | Tom Brady | NE | @ CHI |
| 10 | Andy Dalton | CIN | @ KC |
| 11 | Deshaun Watson | HOU | @ JAX |
| 12 | Drew Brees | NO | @ BAL |
| 13 | Jameis Winston | TB | CLE |
| 14 | Matthew Stafford | DET | @ MIA |
| 15 | Mitchell Trubisky | CHI | NE |
| 16 | Joe Flacco | BAL | NO |
| 17 | Baker Mayfield | CLE | @ TB |
| 18 | Dak Prescott | DAL | @ WAS |
| 19 | C.J. Beathard | SF | LAR |
| 20 | Eli Manning | NYG | @ ATL |
| 21 | Case Keenum | DEN | @ ARI |
| 22 | Sam Darnold | NYJ | MIN |
| 23 | Blake Bortles | JAX | HOU |
| 24 | Marcus Mariota | TEN | @ LAC |
| 25 | Josh Rosen | ARI | DEN |
| 26 | Alex Smith | WAS | DAL |
| 27 | Brock Osweiler | MIA | DET |
| 28 | Derek Anderson | BUF | @ IND |
| 29 | Nathan Peterman | BUF | @ IND |
| 30 | Lamar Jackson | BAL | NO |
** Bye Weeks: Packers, Raiders, Steelers, & Seahawks