By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Todd Gurley II | LAR | @ DEN |
| 2 | James Conner | PIT | @ CIN |
| 3 | Melvin Gordon | LAC | @ CLE |
| 4 | Saquon Barkley | NYG | PHI |
| 5 | Christian McCaffrey | CAR | @ WAS |
| 6 | James White | NE | KC |
| 7 | Kareem Hunt | KC | @ NE |
| 8 | Ezekiel Elliott | DAL | JAX |
| 9 | David Johnson | ARI | @ MIN |
| 10 | Sony Michel | NE | KC |
| 11 | T.J. Yeldon | JAX | @ DAL |
| 12 | Chris Carson | SEA | @ OAK |
| 13 | Marshawn Lynch | OAK | SEA |
| 14 | Dalvin Cook | MIN | ARI |
| 15 | Devonta Freeman | ATL | TB |
| 16 | Joe Mixon | CIN | PIT |
| 17 | Bilal Powell | NYJ | IND |
| 18 | Carlos Hyde | CLE | LAC |
| 19 | Tarik Cohen | CHI | @ MIA |
| 20 | Isaiah Crowell | NYJ | IND |
| 21 | Jordan Howard | CHI | @ MIA |
| 22 | Adrian Peterson | WAS | CAR |
| 23 | Nyheim Hines | IND | @ NYJ |
| 24 | LeSean McCoy | BUF | @ HOU |
| 25 | Corey Clement | PHI | @ NYG |
| 26 | Austin Ekeler | LAC | @ CLE |
| 27 | Tevin Coleman | ATL | TB |
| 28 | Philip Lindsay | DEN | LAR |
| 29 | Chris Thompson | WAS | CAR |
| 30 | Javorius “Buck” Allen | BAL | @ TEN |
| 31 | Wendell Smallwood | PHI | @ NYG |
| 32 | Lamar Miller | HOU | BUF |
| 33 | Dion Lewis | TEN | BAL |
| 34 | Alfred Morris | SF | @ GB |
| 35 | Aaron Jones | GB | SF |
| 36 | Alex Collins | BAL | @ TEN |
| 37 | Peyton Barber | TB | @ ATL |
| 38 | Latavius Murray | MIN | ARI |
| 39 | Duke Johnson Jr. | CLE | LAC |
| 40 | Royce Freeman | DEN | LAR |
| 41 | Kenyan Drake | MIA | CHI |
| 42 | Jalen Richard | OAK | SEA |
| 43 | Mike Davis | SEA | @ OAK |
| 44 | Derrick Henry | TEN | BAL |
| 45 | Jamaal Williams | GB | SF |
| 46 | Kyle Juszczyk | SF | @ GB |
| 47 | Ronald Jones II | TB | @ ATL |
| 48 | Ty Montgomery | GB | SF |
| 49 | Ito Smith | ATL | TB |
| 50 | Jordan Wilkins | IND | @ NYJ |
** Bye Weeks: Lions & Saints