By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Tom Brady | NE | KC |
| 2 | Aaron Rodgers | GB | SF |
| 3 | Patrick Mahomes | KC | @ NE |
| 4 | Matt Ryan | ATL | TB |
| 5 | Kirk Cousins | MIN | ARI |
| 6 | Philip Rivers | LAC | @ CLE |
| 7 | Deshaun Watson | HOU | BUF |
| 8 | Andy Dalton | CIN | PIT |
| 9 | Cam Newton | CAR | @ WAS |
| 10 | Jameis Winston | TB | @ ATL |
| 11 | Andrew Luck | IND | @ NYJ |
| 12 | Jared Goff | LAR | @ DEN |
| 13 | Ben Roethlisberger | PIT | @ CIN |
| 14 | Russell Wilson | SEA | @ OAK |
| 15 | Carson Wentz | PHI | @ NYG |
| 16 | Eli Manning | NYG | PHI |
| 17 | Blake Bortles | JAX | @ DAL |
| 18 | Derek Carr | OAK | SEA |
| 19 | Baker Mayfield | CLE | LAC |
| 20 | Alex Smith | WAS | CAR |
| 21 | Sam Darnold | NYJ | IND |
| 22 | Joe Flacco | BAL | @ TEN |
| 23 | Marcus Mariota | TEN | BAL |
| 24 | C.J. Beathard | SF | @ GB |
| 25 | Mitchell Trubisky | CHI | @ MIA |
| 26 | Case Keenum | DEN | LAR |
| 27 | Dak Prescott | DAL | JAX |
| 28 | Josh Rosen | ARI | @ MIN |
| 29 | Josh Allen | BUF | @ HOU |
| 30 | Ryan Tannehill | MIA | CHI |
** Bye Weeks: Lions & Saints