By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Ezekiel Elliott | DAL | @ HOU |
| 2 | Alvin Kamara | NO | WAS |
| 3 | Todd Gurley II | LAR | @ SEA |
| 4 | Melvin Gordon | LAC | OAK |
| 5 | Christian McCaffrey | CAR | NYG |
| 6 | David Johnson | ARI | @ SF |
| 7 | Saquon Barkley | NYG | @ CAR |
| 8 | Dion Lewis | TEN | @ BUF |
| 9 | Matt Breida | SF | ARI |
| 10 | T.J. Yeldon | JAX | @ KC |
| 11 | Marshawn Lynch | OAK | @ LAC |
| 12 | James Conner | PIT | ATL |
| 13 | Giovani Bernard | CIN | MIA |
| 14 | Mark Ingram II | NO | WAS |
| 15 | Sony Michel | NE | IND |
| 16 | Kareem Hunt | KC | JAX |
| 17 | Philip Lindsay | DEN | @ NYJ |
| 18 | James White | NE | IND |
| 19 | Chris Thompson | WAS | @ NO |
| 20 | Nyheim Hines | IND | @ NE |
| 21 | Derrick Henry | TEN | @ BUF |
| 22 | Tevin Coleman | ATL | @ PIt |
| 23 | Carlos Hyde | CLE | BAL |
| 24 | Javorius “Buck” Allen | BAL | @ CLE |
| 25 | Isaiah Crowell | NYJ | DEN |
| 26 | Alex Collins | BAL | @ CLE |
| 27 | Royce Freeman | DEN | @ NYJ |
| 28 | Aaron Jones | GB | @ DET |
| 29 | Dalvin Cook | MIN | @ PHI |
| 30 | Kerryon Johnson | DET | GB |
| 31 | Bilal Powell | NYJ | DEN |
| 32 | Adrian Peterson | WAS | @ NO |
| 33 | Austin Ekeler | LAC | OAK |
| 34 | Lamar Miller | HOU | DAL |
| 35 | Jay Ajayi | PHI | MIN |
| 36 | Chris Carson | SEA | LAR |
| 37 | Corey Grant | JAX | @ KC |
| 38 | Ty Montgomery | GB | @ DET |
| 39 | Theo Riddick | DET | GB |
| 40 | Kenyan Drake | MIA | @ CIN |
| 41 | LeSean McCoy | BUF | TEN |
| 42 | Alfred Morris | SF | ARI |
| 43 | Jalen Richard | OAK | @ LAC |
| 44 | Duke Johnson Jr. | CLE | BAL |
| 45 | Latavius Murray | MIN | @ PHI |
| 46 | Nick Chubb | CLE | BAL |
| 47 | Devonta Freeman | ATL | @ PIT |
| 48 | Joe Mixon | CIN | MIA |
| 49 | Rashaad Penny | SEA | LAR |
| 50 | LeGarrette Blount | DET | GB |
**Bye Weeks: Bears & Bucs