By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Ben Roethlisberger | PIT | ATL |
| 2 | Kirk Cousins | MIN | @ PHI |
| 3 | Matt Ryan | ATL | @ PIT |
| 4 | Philip Rivers | LAC | OAK |
| 5 | Drew Brees | NO | WAS |
| 6 | Jared Goff | LAR | @ SEA |
| 7 | Carson Wentz | PHI | MIN |
| 8 | Tom Brady | NE | IND |
| 9 | Cam Newton | CAR | NYG |
| 10 | Andrew Luck | IND | @ NE |
| 11 | Deshaun Watson | HOU | DAL |
| 12 | Aaron Rodgers | GB | @ DET |
| 13 | Patrick Mahomes | KC | JAX |
| 14 | Andy Dalton | CIN | MIA |
| 15 | Alex Smith | WAS | @ NO |
| 16 | Marcus Mariota | TEN | @ BUF |
| 17 | Blake Bortles | JAX | @ KC |
| 18 | Matthew Stafford | DET | GB |
| 19 | Derek Carr | OAK | @ LAC |
| 20 | Russell Wilson | SEA | LAR |
| 21 | Ryan Tannehill | MIA | @ CIN |
| 22 | Joe Flacco | BAL | @ CLE |
| 23 | Dak Prescott | DAL | @ HOU |
| 24 | Baker Mayfield | CLE | BAL |
| 25 | Josh Rosen | ARI | @ SF |
| 26 | C.J. Beathard | SF | ARI |
| 27 | Eli Manning | NYG | @ CAR |
| 28 | Case Keenum | DEN | @ NYJ |
| 29 | Sam Darnold | NYJ | DEN |
| 30 | Josh Allen | BUF | TEN |
**Bye Weeks: Bears & Bucs