By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Alvin Kamara | NO | NYG |
| 2 | Ezekiel Elliott | DAL | DET |
| 3 | Melvin Gordon | LAC | SF |
| 4 | Todd Gurley II | LAR | MIN |
| 5 | David Johnson | ARI | SEA |
| 6 | James Conner | PIT | BAL |
| 7 | Saquon Barkley | NYG | @ NO |
| 8 | Leonard Fournette | JAX | NYJ |
| 9 | Lamar Miller | HOU | @ IND |
| 10 | Kareem Hunt | KC | @ DEN |
| 11 | Giovani Bernard | CIN | @ ATL |
| 12 | Carlos Hyde | CLE | @ OAK |
| 13 | Jordan Howard | CHI | TB |
| 14 | Marshawn Lynch | OAK | CLE |
| 15 | Philip Lindsay | DEN | KC |
| 16 | Chris Carson | SEA | @ ARI |
| 17 | Kerryon Johnson | DET | @ DAL |
| 18 | Tevin Coleman | ATL | CIN |
| 19 | James White | NE | MIA |
| 20 | Javorius “Buck” Allen | BAL | @ PIT |
| 21 | Matt Breida | SF | @ LAC |
| 22 | Dalvin Cook | MIN | @ LAR |
| 23 | Alex Collins | BAL | @ PIT |
| 24 | Jay Ajayi | PHI | @ TEN |
| 25 | Dion Lewis | TEN | PHI |
| 26 | Devonta Freeman | ATL | CIN |
| 27 | Sony Michel | NE | MIA |
| 28 | Royce Freeman | DEN | KC |
| 29 | Theo Riddick | DET | @ DAL |
| 30 | Ty Montgomery | GB | BUF |
| 31 | LeSean McCoy | BUF | @ GB |
| 32 | Bilal Powell | NYJ | @ JAX |
| 33 | Austin Ekeler | LAC | SF |
| 34 | Alfred Morris | SF | @ LAC |
| 35 | Isaiah Crowell | NYJ | @ JAX |
| 36 | Jordan Wilkins | IND | HOU |
| 37 | Nyheim Hines | IND | HOU |
| 38 | Chris Ivory | BUF | @ GB |
| 39 | Jamaal Williams | GB | BUF |
| 40 | Derrick Henry | TEN | PHI |
| 41 | Tarik Cohen | CHI | TB |
| 42 | Peyton Barber | TB | @ CHI |
| 43 | Rex Burkhead | NE | MIA |
| 44 | Rashaad Penny | SEA | @ ARI |
| 45 | Aaron Jones | GB | BUF |
| 46 | Duke Johnson Jr. | CLE | @ OAK |
| 47 | Darren Sproles | PHI | @ TEN |
| 48 | Chase Edmonds | ARI | SEA |
| 49 | Jalen Richard | OAK | CLE |
| 50 | LeGarrette Blount | DET | @ DAL |
| 51 | Latavius Murray | MIN | @ LAR |
| 52 | Jacquizz Rodgers | TB | @ CHI |
| 53 | Frank Gore | MIA | @ NE |
| 54 | Corey Clement | PHI | @ TEN |
| 55 | Marcus Murphy | BUF | @ GB |
**Bye Weeks: Panthers & Redskins