By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Patrick Mahomes | KC | @ DEN |
| 2 | Aaron Rodgers | GB | BUF |
| 3 | Ben Roethlisberger | PIT | BAL |
| 4 | Philip Rivers | LAC | SF |
| 5 | Matt Ryan | ATL | CIN |
| 6 | Drew Brees | NO | @ NYG |
| 7 | Carson Wentz | PHI | @ TEN |
| 8 | Deshaun Watson | HOU | @ IND |
| 9 | Tom Brady | NE | MIA |
| 10 | Kirk Cousins | MIN | @ LAR |
| 11 | Jared Goff | LAR | MIN |
| 12 | Ryan Tannehill | MIA | @ NE |
| 13 | Matthew Stafford | DET | @ DAL |
| 14 | Andrew Luck | IND | HOU |
| 15 | Andy Dalton | CIN | @ ATL |
| 16 | Baker Mayfield | CLE | @ OAK |
| 17 | Ryan Fitzpatrick | TB | @ CHI |
| 18 | Eli Manning | NYG | NO |
| 19 | Joe Flacco | BAL | @ PIT |
| 20 | Russell Wilson | SEA | @ ARI |
| 21 | Case Keenum | DEN | KC |
| 22 | Mitchell Trubisky | CHI | TB |
| 23 | Blake Bortles | JAX | NYJ |
| 24 | Josh Allen | BUF | @ GB |
| 25 | Derek Carr | OAK | CLE |
| 26 | Josh Rosen | ARI | SEA |
| 27 | Dak Prescott | DAL | DET |
| 28 | C.J. Beathard | SF | @ LAC |
| 29 | Marcus Mariota | TEN | PHI |
| 30 | Sam Darnold | NYJ | @ JAX |
**Bye Weeks: Panthers & Redskins