By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | FLEX | TE | D/ST |
| Player | Team | Opponent | |
| 1 | Ezekiel Elliott | DAL | @SF |
| 2 | Leonard Fournette | JAX | @IND |
| 3 | Devonta Freeman | ATL | @NE |
| 4 | LeSean McCoy | BUF | CAR |
| 5 | Jay Ajayi | MIA | NYJ |
| 6 | Kareem Hunt | KC | @OAK |
| 7 | Carlos Hyde | SF | DAL |
| 8 | Le’Veon Bell | PIT | CIN |
| 9 | Mark Ingram | NO | GB |
| 10 | Todd Gurley | LAR | ARI |
| 11 | Melvin Gordon | LAC | DEN |
| 12 | DeMarco Murray | TEN | @CLE |
| 13 | Adrian Peterson | ARI | @LAR |
| 14 | C.J. Anderson | DEN | @LAC |
| 15 | Ty Montgomery | GB | NO |
| 16 | Jerick McKinnon | MIN | BAL |
| 17 | Jordan Howard | CHI | CAR |
| 18 | Chris Thompson | WSH | @PHI |
| 19 | Duke Johnson Jr. | CLE | TEN |
| 20 | Tevin Coleman | ATL | @NE |
| 21 | Alvin Kamara | NO | @GB |
| 22 | Christian McCaffrey | CAR | @CHI |
| 23 | James White | NE | ATL |
| 24 | Joe Mixon | CIN | @PIT |
| 25 | Frank Gore | IND | JAX |
| 26 | LeGarrette Blount | PHI | WSH |
| 27 | Aaron Jones | GB | NO |
| 28 | Doug Martin | TB | @BUF |
| 29 | Javorius Allen | BAL | @MIN |
| 30 | Mike Gillislee | NE | ATL |
| 31 | Marshawn Lynch | OAK | KC |
| 32 | Giovani Bernard | CIN | @PIT |
| 33 | Tarik Cohen | CHI | CAR |
| 34 | Andre Ellington | ARI | @LAR |
| 35 | Jonathan Stewart | CAR | @CHI |
| 36 | Derrick Henry | TEN | @CLE |
| 37 | Isaiah Crowell | CLE | TEN |
| 38 | Matt Forte | NYJ | @MIA |
| 39 | Alex Collins | BAL | @MIN |
| 40 | Orleans Darkwa | NYG | SEA |
| 41 | Latavius Murray | MIN | BAL |
| 42 | Wendell Smallwood | PHI | WSH |
| 43 | Bilal Powell | NYJ | @MIA |
| 44 | Chris Ivory | JAX | @IND |
| 45 | Eddie Lacy | SEA | @NYG |
| 46 | Matt Breida | SF | DAL |
| 47 | Charles Sims | TB | @BUF |
| 48 | C.J. Prosise | SEA | @NYG |
| 49 | Dion Lewis | NE | @ATL |
| 50 | Wayne Gallman | NYG | SEA |
**Week 7 byes: Lions & Texans