By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | FLEX | TE | D/ST |
| Player | Team | Opponent | |
| 1 | Kareem Hunt | KC | PIT |
| 2 | Leonard Fournette | JAX | LAR |
| 3 | Todd Gurley | LAR | @JAX |
| 4 | Melvin Gordon | LAC | @OAK |
| 5 | Le’Veon Bell | PIT | @KC |
| 6 | Jordan Howard | CHI | @BAL |
| 7 | Devonta Freeman | ATL | MIA |
| 8 | C.J. Anderson | DEN | NYG |
| 9 | DeMarco Murray | TEN | IND |
| 10 | Lamar Miller | HOU | CLE |
| 11 | Ameer Abdullah | DET | @NO |
| 12 | Duke Johnson Jr. | CLE | @HOU |
| 13 | Chris Thompson | WSH | SF |
| 14 | Christian McCaffrey | CAR | PHI |
| 15 | Mark Ingram | NO | DET |
| 16 | Mike Gillislee | NE | @NYJ |
| 17 | Carlos Hyde | SF | @WSH |
| 18 | Javorius Allen | BAL | CHI |
| 19 | Alvin Kamara | NO | DET |
| 20 | Ty Montgomery | GB | @MIN |
| 21 | Andre Ellington | ARI | TB |
| 22 | Elijah McGuire | NYJ | NE |
| 23 | Jerick McKinnon | MIN | GB |
| 24 | James White | NE | @NYJ |
| 25 | Tevin Coleman | ATL | MIA |
| 26 | LeGarrette Blount | PHI | @CAR |
| 27 | Theo Riddick | DET | @NO |
| 28 | Alex Collins | BAL | CHI |
| 29 | Frank Gore | IND | @TEN |
| 30 | Rob Kelley | WSH | SF |
| 31 | Marshawn Lynch | OAK | LAC |
| 32 | Jay Ajayi | MIA | @ATL |
| 33 | Doug Martin | TB | @ARI |
| 34 | Matt Breida | SF | @WSH |
| 35 | Tarik Cohen | CHI | @BAL |
| 36 | Latavius Murray | MIN | GB |
| 37 | Isaiah Crowell | CLE | @HOU |
| 38 | Jonathan Stewart | CAR | PHI |
| 39 | Derrick Henry | TEN | IND |
| 40 | Wayne Gallman | NYG | @DEN |
| 41 | Charcandrick West | KC | PIT |
| 42 | Aaron Jones | GB | @MIN |
| 43 | Corey Clement | PHI | @CAR |
| 44 | Jalen Richard | OAK | LAC |
| 45 | Charles Sims | TB | @ARI |
| 46 | Shane Vereen | NYG | @DEN |
| 47 | DeAndre Washington | OAK | LAC |
| 48 | D’Onta Foreman | HOU | CLE |
| 49 | Marlon Mack | IND | @TEN |
| 50 | Adrian Peterson | ARI | TB |
| 51 | Jamaal Charles | DEN | NYG |
| 52 | Orleans Darkwa | NYG | @DEN |
| 53 | Kenyan Drake | MIA | @ATL |
| 54 | Dion Lewis | NE | @NYJ |
| 55 | Malcolm Brown | LAR | @JAX |
** Week 6 byes: Bills, Bengals, Cowboys, Seahawks