By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | FLEX | TE | D/ST |
| Player | Team | Opponent | |
| 1 | Deshaun Watson | HOU | CLE |
| 2 | Tom Brady | NE | @NYJ |
| 3 | Matt Ryan | ATL | MIA |
| 4 | Kirk Cousins | WSH | SF |
| 5 | Drew Brees | NO | DET |
| 6 | Marcus Mariota | TEN | IND |
| 7 | Matthew Stafford | DET | @NO |
| 8 | Aaron Rodgers | GB | @MIN |
| 9 | Carson Palmer | ARI | TB |
| 10 | Cam Newton | CAR | PHI |
| 11 | Jameis Winston | TB | @ARI |
| 12 | Philip Rivers | LAC | @OAK |
| 13 | Carson Wentz | PHI | @CAR |
| 14 | Alex Smith | KC | PIT |
| 15 | Jacoby Brissett | IND | @TEN |
| 16 | Trevor Siemian | DEN | NYG |
| 17 | Case Keenum | MIN | GB |
| 18 | Josh McCown | NYJ | NE |
| 19 | Derek Carr | OAK | LAC |
| 20 | Kevin Hogan | CLE | @HOU |
| 21 | Ben Roethlisberger | PIT | @KC |
| 22 | Joe Flacco | BAL | CHI |
| 23 | Blake Bortles | JAX | LAR |
| 24 | Brian Hoyer | SF | @WSH |
| 25 | Jared Goff | LAR | @JAX |
| 26 | Eli Manning | NYG | @DEN |
| 27 | Jay Cutler | MIA | @ATL |
| 28 | Mitchell Trubisky | CHI | @BAL |
** Week 6 byes: Bills, Bengals, Cowboys, Seahawks