By The Hudsonian, Joshua Hudson
| Click Here for: | RB | WR | FLEX | TE | D/ST |
| Player | Team | Opponent | |
| 1 | Aaron Rodgers | GB | @DAL |
| 2 | Tom Brady | NE | @TB |
| 3 | Dak Prescott | DAL | GB |
| 4 | Matthew Stafford | DET | CAR |
| 5 | Carson Wentz | PHI | ARI |
| 6 | Jameis Winston | TB | NE |
| 7 | Sam Bradford | MIN | @CHI |
| 8 | Marcus Mariota | TEN | @MIA |
| 9 | Russell Wilson | SEA | @LAR |
| 10 | Deshaun Watson | HOU | KC |
| 11 | Eli Manning | NYG | LAC |
| 12 | Carson Palmer | ARI | @PHI |
| 13 | Alex Smith | KC | @HOU |
| 14 | Jacoby Brissett | IND | SF |
| 15 | Philip Rivers | LAC | @NYG |
| 16 | Tyrod Taylor | BUF | @CIN |
| 17 | Ben Roethlisberger | PIT | JAX |
| 18 | Cam Newton | CAR | @DET |
| 19 | Joe Flacco | BAL | @OAK |
| 20 | Brian Hoyer | SF | @IND |
| 21 | Andy Dalton | CIN | BUF |
| 22 | DeShone Kizer | CLE | NYJ |
| 23 | Jared Goff | LAR | SEA |
| 24 | Jay Cutler | MIA | TEN |
| 25 | Josh McCown | NYJ | @CLE |
| 26 | EJ Manuel | OAK | BAL |
| 27 | Blake Bortles | JAX | @PIT |
| 28 | Mitchell Trubisky | CHI | MIN |
** Week 5 byes: Falcons, Redskins, Broncos, & Saints