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Fantasy Football Week 2 Start/Sit: Matchups to Target and Avoid

Ryan Weisse
Fantasy Football 2026

Club Fantasy’s Weekly Fantasy Football Matchup Report is here to help you set winning lineups. Each week, we highlight the ten defenses allowing the most points to QBs, RBs, WRs, and TEs, along with the five toughest matchups. Use this data to guide your start/sit decisions or build a DFS lineup that can win the slate. Here are the matchups to target and avoid for NFL Week 2.

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Fantasy Football Week 2 Start/Sit Advice

Scoring Note: These rankings use the full PPR scoring format. However, there is not a big difference between the rankings in .5 or non-PPR scoring.

Quarterback Matchups

Most Points Allowed Last Week (Matchups to Target):

  1. CAR: plays @ ATL, consider Tua Tagovailoa or Cooper Rush.
  2. HOU: plays vs CIN, consider Joe Burrow.
  3. CHI: plays vs MIN, consider Carson Wentz or Kyler Murray.
  4. IND: plays @ KC, consider Patrick Mahomes.
  5. DAL: plays vs WAS, consider Jayden Daniels.
  6. CLE: plays @ TB, consider Baker Mayfield.
  7. DET: plays @ BUF, consider Josh Allen.
  8. WAS: plays @ DAL, consider Dak Prescott.
  9. DEN: plays vs JAX, consider Trevor Lawrence.
  10. MIN: plays @ CHI, consider Caleb Williams.

Fewest Points Allowed Last Week (Matchups to Fade):

  1. SF: plays vs MIA, fade Malik Willis.
  2. PIT: plays @ NE, fade Drake Maye.
  3. KC: plays vs IND, fade Daniel Jones.
  4. BAL: plays vs NO, fade Tyler Shough.
  5. TEN: plays vs PHI, fade Jalen Hurts.

Running Back Matchups

Most Points Allowed Last Week (Matchups to Target):

  1. CAR: plays @ ATL, consider Bijan Robinson.
  2. DEN: plays vs JAX, consider Bhayshul Tuten.
  3. IND: plays @ KC, consider Kenneth Walker.
  4. NO: plays @ BAL, consider Derrick Henry.
  5. MIA: plays @ SF, consider Christian McCaffrey and Kaelon Black.
  6. PIT: plays @ NE, consider Rhamondre Stevenson and TreVeyon Henderson.
  7. BUF: plays vs DET, consider Jahmyr Gibbs.
  8. CHI: plays vs MIN, consider Jordan Mason and Aaron Jones.
  9. DAL: plays vs WAS, consider Jacory Croskey-Merritt and Rachaad White.
  10. BAL: plays vs NO, consider Travis Etienne.

Fewest Points Allowed Last Week (Matchups to Fade):

  1. MIN: plays @ CHI, fade D’Andre Swift and Kyle Monangai.
  2. NYJ: plays vs GB, fade MarShawn Lloyd.
  3. LV: plays @ LAC, fade Omarion Hampton.
  4. HOU: plays vs CIN, fade Chase Brown.
  5. ARI: plays vs SEA, fade Jadarian Price.

Wide Receiver Matchups

Most Points Allowed Last Week (Matchups to Target):

  1. DET: plays @ BUF, consider DJ Moore and Khalil Shakir.
  2. MIN: plays @ CHI, consider Rome Odunze, Luther Burden, and Kalif Raymond.
  3. CLE: plays @ TB, consider Emeka Egbuka and Chris Godwin.
  4. LAR: plays vs NYG, consider Malik Nabers and Malachi Fields.
  5. CHI: plays vs MIN, consider Justin Jefferson and Jordan Addison.
  6. CAR: plays @ ATL, consider Drake London.
  7. HOU: plays vs CIN, consider Ja’Marr Chase and Tee Higgins.
  8. BUF: plays vs DET, consider Amon-Ra St. Brown and Jameson Williams.
  9. IND: plays @ KC, consider Rashee Rice.
  10. NO: plays @ BAL, consider Zay Flowers and Rashod Bateman.

Fewest Points Allowed Last Week (Matchups to Fade):

  1. PIT: plays @ NE, fade Romeo Doubs and Mack Hollins.
  2. KC: plays vs IND, fade Josh Downs and Alec Pierce.
  3. DEN: plays vs JAX, fade Brian Thomas Jr., Parker Washington, and Jakobi Meyers.
  4. TB: plays vs CLE, fade KC Concepcion, Denzel Boston, and Jerry Jeudy.
  5. SF: plays vs MIA, fade Caleb Douglas, Malik Washington, and Chris Bell.

Tight End Matchups

Most Points Allowed Last Week (Matchups to Target):

  1. DAL: plays vs WAS, consider Chig Okonkwo.
  2. DET: plays @ BUF, consider Dalton Kincaid.
  3. TB: plays vs CLE, consider Harold Fannin.
  4. LAC: plays vs LV, consider Brock Bowers or Michael Mayer.
  5. WAS: plays @ DAL, consider Jake Ferguson.
  6. HOU: plays vs CIN, consider Mike Gesicki.
  7. ATL: plays vs CAR, consider Darren Waller.
  8. GB: plays @ NYJ, consider Kenyon Sadiq.
  9. KC: plays vs IND, consider Tyler Warren.
  10. MIN: plays @ CHI, consider Colston Loveland.

Fewest Points Allowed Last Week (Matchups to Fade):

  1. PIT: plays @ NE, fade Hunter Henry.
  2. NE: plays vs PIT, fade Pat Freiermuth.
  3. LV: plays @ LAC, fade Oronde Gadsden and David Njoku.
  4. CIN: plays @ HOU, fade Dalton Schultz.
  5. JAX: plays @ DEN, fade Evan Engram.

Are you looking for more help with NFL Week 2?

Here are Club Fantasy’s Week 2 rankings! Also, you’ll find the rest of our fantasy football articles here!

Finally, don’t forget to tune in to our YouTube channel every Wednesday at 9 pm EST for No Punt Intended. Josh, Joe, and Ryan will help get you ready for your Week 2 fantasy matchups!

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