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Fantasy Football Week 12 Start/Sit: Matchups to Target and Avoid

Ryan Weisse
Fantasy Football 2025

Welcome to Club Fantasy’s Weekly Start/Sit Matchup Report, a data-driven guide to setting winning lineups. Each week, we highlight the defenses allowing the most and fewest fantasy points to quarterbacks, running backs, wide receivers, and tight ends over the last four weeks.

This isn’t just season-long data you’ll find on most sites; it’s recent, actionable info to help you spot hot and cold matchups before your competition does. Use it to guide your start/sit decisions or build a DFS lineup that can win the slate.

Here are the fantasy matchups to target and avoid for NFL Week 12.

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Fantasy Football Week 12 Start Sit Advice

Scoring Note: These rankings use the full PPR scoring format. However, there is not a big difference between the rankings in .5 or non-PPR scoring.

Most Points Allowed (Matchups to Target)

  1. SF: plays CAR, consider Bryce Young
  2. CIN: plays NE, consider Drake Maye
  3. TB: plays @ LAR, consider Matthew Stafford
  4. ATL: plays @ NO, consider Tyler Shough
  5. NYG: plays @ DET, consider Jared Goff
  6. TEN: plays SEA, consider Sam Darnold
  7. CHI: plays PIT, consider Aaron Rodgers (may be out), or Mason Rudolph
  8. DAL: plays PHI, consider Jalen Hurts
  9. WAS: BYE
  10. NYJ: plays @ BAL, consider Lamar Jackson

Fewest Points Allowed (Matchups to Fade)

  1. LAC: BYE
  2. BAL: plays NYJ, fade Tyrod Taylor
  3. DEN: BYE
  4. BUF: plays @ HOU, fade C.J. Stroud
  5. GB: plays MIN, fade J.J. McCarthy

Running Back Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

  1. CIN: plays NE, consider TreVeyon Henderson and Rhamondre Stevenson
  2. ATL: plays @ NO, consider Alvin Kamara
  3. NYG: plays @ DET, consider Jahmyr Gibbs and David Montgomery
  4. CAR: plays @ SF, consider Christian McCaffrey
  5. WAS: BYE
  6. NYJ: plays @ BAL, consider Derrick Henry
  7. BUF: plays @ HOU, consider Woody Marks
  8. ARI: plays JAX, consider Travis Etienne
  9. IND: plays @ KC, consider Kareem Hunt and Isiah Pacheco
  10. TB: plays @ LAR, consider Kyren Williams

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

  1. NE: plays @ CIN, fade Chase Brown
  2. DET: plays NYG, fade Tyrone Tracy and Devin Singletary
  3. DEN: BYE
  4. BAL: plays NYJ, fade Breece Hall
  5. JAX: plays @ ARI, fade Bam Knight and Michael Carter

Wide Receiver Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

  1. SF: plays CAR, consider Tetairoa McMillan and Xavier Legette
  2. TEN: plays SEA, consider Jaxon Smith-Njigba
  3. TB: plays @ LAR, consider Puka Nacua and Davante Adams
  4. WAS: BYE
  5. ATL: plays @ NO, consider Chris Olave
  6. PIT: plays @ CHI, consider D.J. Moore and Rome Odunze
  7. LV: plays CLE, consider Jerry Jeudy and Cedric Tillman
  8. CHI: plays PIT, consider DK Metcalf
  9. DAL: plays PHI, consider A.J. Brown and DeVonta Smith
  10. BAL: plays NYJ, consider John Metchie and Adonai Mitchell

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

  1. PHI: plays @ DAL, fade CeeDee Lamb and George Pickens
  2. CLE: plays @ LV, fade Tre Tucker
  3. LAC: BYE
  4. IND: plays @ KC, fade Rashee Rice and Xavier Worthy
  5. HOU: plays BUF, fade Khalil Shakir and Josh Palmer

Tight End Matchups

Most Points Allowed Last 4 Weeks (Matchups to Target)

  1. JAX: plays @ ARI, consider Trey McBride
  2. CIN: plays NE, consider Hunter Henry
  3. LAR: plays TB, consider Cade Otton
  4. MIA: BYE
  5. SF: plays CAR, consider Ja’Tavian Sanders and Tommy Tremble
  6. MIN: plays @ GB, consider Luke Musgrave
  7. SEA: plays @ TEN, consider Chigoziem Okonkwo
  8. IND: plays @ KC, consider Travis Kelce
  9. NE: plays @ CIN, consider Noah Fant
  10. DAL: plays PHI, consider Dallas Goedert

Fewest Points Allowed Last 4 Weeks (Matchups to Fade)

  1. PHI: plays @ DAL, fade Jake Ferguson
  2. GB: plays MIN, fade T.J. Hockenson
  3. BUF: plays @ HOU, fade Dalton Schultz
  4. LV: plays CLE, fade David Njoku and Harold Fannin
  5. TB: plays @ LAR, fade Tyler Higbee

Are you looking for more help with NFL Week 12?

Here are Club Fantasy’s Week 12 rankings! Also, you’ll find the rest of our fantasy football articles here!

Finally, don’t forget to tune into our YouTube channel every Wednesday at 8 pm EST for No Punt Intended. Josh, Joe, and Ryan will help get you ready for your Week 12 fantasy matchups!

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