By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Christian McCaffrey | CAR | @ TB |
| 2 | Todd Gurley II | LAR | @ DET |
| 3 | Kareem Hunt | KC | @ OAK |
| 4 | Aaron Jones | GB | ARI |
| 5 | Saquon Barkley | NYG | CHI |
| 6 | Ezekiel Elliott | DAL | NO |
| 7 | Alvin Kamara | NO | @ DAL |
| 8 | James Conner | PIT | LAC |
| 9 | Nick Chubb | CLE | @ HOU |
| 10 | Philip Lindsay | DEN | @ CIN |
| 11 | David Johnson | ARI | @ GB |
| 12 | Lamar Miller | HOU | CLE |
| 13 | T.J. Yeldon | JAX | IND |
| 14 | Joe Mixon | CIN | DEN |
| 15 | Matt Breida | SF | @ SEA |
| 16 | Tarik Cohen | CHI | @ NYG |
| 17 | Adrian Peterson | WAS | @ PHI |
| 18 | Gus Edwards | BAL | @ ATL |
| 19 | Austin Ekeler | LAC | @ PIT |
| 20 | Kerryon Johnson | DET | LAR |
| 21 | Dalvin Cook | MIN | @ NE |
| 22 | Kenyan Drake | MIA | BUF |
| 23 | Dion Lewis | TEN | NYJ |
| 24 | LeSean McCoy | BUF | @ MIA |
| 25 | Josh Adams | PHI | WAS |
| 26 | Sony Michel | NE | MIN |
| 27 | Chris Carson | SEA | SF |
| 28 | James White | NE | MIN |
| 29 | Doug Martin | OAK | KC |
| 30 | Tevin Coleman | ATL | BAL |
| 31 | Jalen Richard | OAK | KC |
| 32 | Carlos Hyde | JAX | IND |
| 33 | Mark Ingram II | NO | @ DAL |
| 34 | Duke Johnson Jr. | CLE | @ HOU |
| 35 | Theo Riddick | DET | LAR |
| 36 | Frank Gore | MIA | BUF |
| 37 | Justin Jackson | LAC | @ PIT |
| 38 | Marlon Mack | IND | @ JAX |
| 39 | Peyton Barber | TB | CAR |
| 40 | Royce Freeman | DEN | @ CIN |
| 41 | Nyheim Hines | IND | @ JAX |
| 42 | Jordan Howard | CHI | @ NYG |
| 43 | Isaiah Crowell | NYJ | @ TEN |
| 44 | Ito Smith | ATL | BAL |
| 45 | Kapri Bibbs | WAS | @ PHI |
| 46 | LeGarrette Blount | DET | LAR |
| 47 | Ty Montgomery | BAL | @ ATL |
| 48 | Jordan Wilkins | IND | @ JAX |
| 49 | Corey Clement | PHI | WAS |
| 50 | Chris Thompson | WAS | @ PHI |
| 51 | Alfred Blue | HOU | CLE |
| 52 | Taquan Mizzell | CHI | @ NYG |
| 53 | Rashaad Penny | SEA | SF |
| 54 | Mike Davis | SEA | SF |
| 55 | Elijah McGuire | NYJ | @ TEN |