By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | TE | FLEX | D/ST |
| Player | Team | Opponent | |
| 1 | Saquon Barkley | NYG | @ ATL |
| 2 | Todd Gurley II | LAR | @ SF |
| 3 | David Johnson | ARI | DEN |
| 4 | Melvin Gordon | LAC | TEN |
| 5 | Kareem Hunt | KC | CIN |
| 6 | Joe Mixon | CIN | @ KC |
| 7 | Ezekiel Elliott | DAL | @ WAS |
| 8 | Mark Ingram | NO | @ BAL |
| 9 | Christian McCaffrey | CAR | @ PHI |
| 10 | Philip Lindsay | DEN | @ ARI |
| 11 | Alvin Kamara | NO | @ BAL |
| 12 | Tevin Coleman | ATL | NYG |
| 13 | Sony Michel | NE | @ CHI |
| 14 | Royce Freeman | DEN | @ ARI |
| 15 | Kerryon Johnson | DET | @ MIA |
| 16 | T.J. Yeldon | JAX | HOU |
| 17 | Tarik Cohen | CHI | NE |
| 18 | Carlos Hyde | CLE | @ TB |
| 19 | Kenyan Drake | MIA | DET |
| 20 | Matt Breida | SF | LAR |
| 21 | LeSean McCoy | BUF | @ IND |
| 22 | Adrian Peterson | WAS | DAL |
| 23 | Peyton Barber | TB | CLE |
| 24 | Duke Johnson Jr. | CLE | @ TB |
| 25 | Latavius Murray | MIN | @ NYJ |
| 26 | Frank Gore | MIA | DET |
| 27 | Isaiah Crowell | NYJ | MIN |
| 28 | James White | NE | @ CHI |
| 29 | Ito Smith | ATL | NYG |
| 30 | Dion Lewis | TEN | @ LAC |
| 31 | Jordan Howard | CHI | NE |
| 32 | Chris Thompson | WAS | DAL |
| 33 | Wendell Smallwood | PHI | CAR |
| 34 | Bilal Powell | NYJ | MIN |
| 35 | Corey Clement | PHI | CAR |
| 36 | Javorius “Buck” Allen | BAL | NO |
| 37 | Nyheim Hines | IND | BUF |
| 38 | Alex Collins | BAL | NO |
| 39 | Marlon Mack | IND | BUF |
| 40 | Lamar Miller | HOU | @ JAX |
| 41 | Austin Ekeler | LAC | TEN |
| 42 | Alfred Morris | SF | LAR |
| 43 | LeGarrette Blount | DET | @ MIA |
| 44 | Alfred Blue | HOU | @ JAX |
| 45 | Jamaal Charles | JAX | HOU |
| 46 | Ronald Jones II | TB | CLE |
| 47 | Raheem Mostart | SF | LAR |
| 48 | Devontae Booker | DEN | @ ARI |
| 49 | Theo Riddick | DET | @ MIA |
| 50 | Chris Ivory | BUF | @ IND |
** Bye Weeks: Packers, Raiders, Steelers, & Seahawks