By The Hudsonian, Joshua Hudson
| Click Here for: | QB | WR | FLEX | TE | D/ST |
| Player | Team | Opponent | |
| 1 | Le’Veon Bell | PIT | JAX |
| 2 | Leonard Fournette | JAX | @PIT |
| 3 | Ezekiel Elliott | DAL | GB |
| 4 | Kareem Hunt | KC | @HOU |
| 5 | Todd Gurley | LAR | SEA |
| 6 | DeMarco Murray | TEN | @MIA |
| 7 | LeSean McCoy | BUF | @CIN |
| 8 | Carlos Hyde | SF | @IND |
| 9 | Frank Gore | IND | SF |
| 10 | Melvin Gordon | LAC | @NYG |
| 11 | Duke Johnson Jr. | CLE | NYJ |
| 12 | Aaron Jones | GB | @DAL |
| 13 | Lamar Miller | HOU | KC |
| 14 | Ameer Abdullah | DET | CAR |
| 15 | Jordan Howard | CHI | MIN |
| 16 | Jay Ajayi | MIA | TEN |
| 17 | Bilal Powell | NYJ | @CLE |
| 18 | Christian McCaffrey | CAR | @DET |
| 19 | Javorius Allen | BAL | @OAK |
| 20 | LeGarrette Blount | PHI | ARI |
| 21 | Latavius Murray | MIN | @CHI |
| 22 | Tarik Cohen | CHI | MIN |
| 23 | Andre Ellington | ARI | @PHI |
| 24 | Isaiah Crowell | CLE | NYJ |
| 25 | Jacquizz Rodgers | TB | NE |
| 26 | Marshawn Lynch | OAK | BAL |
| 27 | James White | NE | @TB |
| 28 | Joe Mixon | CIN | BUF |
| 29 | Jonathan Stewart | CAR | @DET |
| 30 | Theo Riddick | DET | CAR |
| 31 | Mike Gillislee | NE | @TB |
| 32 | Shane Vereen | NYG | LAC |
| 33 | Alex Collins | BAL | @OAK |
| 34 | Doug Martin | TB | NE |
| 35 | Giovani Bernard | CIN | BUF |
| 36 | Chris Johnson | ARI | @PHI |
| 37 | Eddie Lacy | SEA | @LAR |
| 38 | Jerick McKinnon | MIN | @CHI |
| 39 | Wendell Smallwood | PHI | ARI |
| 40 | Derrick Henry | TEN | @MIA |
| 41 | Charles Sims | TB | NE |
| 42 | Wayne Gallman | NYG | LAC |
| 43 | Elijah McGuire | NYJ | @CLE |
| 44 | C.J. Prosise | SEA | @LAR |
| 45 | Robert Turbin | IND | SF |
| 46 | Matt Breida | SF | @IND |
| 47 | Thomas Rawls | SEA | @LAR |
| 48 | D’Onta Foreman | HOU | KC |
| 49 | Charcandrick West | KC | @HOU |
| 50 | Jalen Richard | OAK | BAL |
| 51 | Jeremy Hill | CIN | BUF |
| 52 | Branden Oliver | LAC | @NYG |
| 53 | Terrance West | BAL | @OAK |
| 54 | Kenyan Drake | MIA | TEN |
| 55 | Corey Clement | PHI | ARI |
** Week 5 byes: Falcons, Redskins, Broncos, & Saints